Evidence map›Paper›PMID 35136068›Full record

ArticleNature communications2022

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.

Dinesh Aggarwal, Ben Warne, Aminu S Jahun, William L Hamilton, Thomas Fieldman, Louis du Plessis, Verity Hill, Beth Blane, Emmeline Watkins, Elizabeth Wright and 33 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 52 citations in OpenAlex.

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  19. Colonization and transmission ofMicrobial genomics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 20 institutions in 2 countries.

Dinesh Aggarwal *University of Cambridge, Department of Medicine, Cambridge, UK. dinesh.aggarwal@nhs.net.ORCID 0000-0002-5938-8172
Ben Warne *University of Cambridge, Department of Medicine, Cambridge, UK.ORCID 0000-0003-1326-0373
Aminu S JahunUniversity of Cambridge, Department of Pathology, Division of Virology, Cambridge, UK.ORCID 0000-0002-4585-1701
William L HamiltonUniversity of Cambridge, Department of Medicine, Cambridge, UK.ORCID 0000-0002-3330-353X
Thomas FieldmanUniversity of Cambridge, Department of Medicine, Cambridge, UK.
Louis du PlessisDepartment of Zoology, University of Oxford, Oxford, UK.ORCID 0000-0003-0352-6289
Verity HillInstitute of Evolutionary Virology, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-3509-8146
Beth BlaneUniversity of Cambridge, Department of Medicine, Cambridge, UK.ORCID 0000-0002-0996-9091
Emmeline WatkinsPublic Health Directorate, Cambridgeshire County Council and Peterborough City Council, Peterborough, UK.
Elizabeth WrightPublic Health Directorate, Cambridgeshire County Council and Peterborough City Council, Peterborough, UK.ORCID 0000-0002-8378-9072
Grant HallUniversity of Cambridge, Department of Pathology, Division of Virology, Cambridge, UK.ORCID 0000-0003-3928-3979
Catherine LuddenUniversity of Cambridge, Department of Medicine, Cambridge, UK.
Richard MyersPublic Health England, 61 Colindale Ave, London, NW9 5EQ, UK.
Myra HosmilloCambridge University Hospital NHS Foundation Trust, Cambridge, UK.
Yasmin ChaudhryUniversity of Cambridge, Department of Pathology, Division of Virology, Cambridge, UK.ORCID 0000-0002-2386-3269
Malte L PinckertUniversity of Cambridge, Department of Pathology, Division of Virology, Cambridge, UK.ORCID 0000-0002-6072-5949
Iliana GeorganaUniversity of Cambridge, Department of Pathology, Division of Virology, Cambridge, UK.
Rhys IzuagbeUniversity of Cambridge, Department of Pathology, Division of Virology, Cambridge, UK.ORCID 0000-0001-8080-2510
Danielle LeekUniversity of Cambridge, Department of Medicine, Cambridge, UK.
Olisaeloka NsonwuPublic Health England, 61 Colindale Ave, London, NW9 5EQ, UK.ORCID 0000-0002-3024-700X
Gareth J HughesPublic Health England, 61 Colindale Ave, London, NW9 5EQ, UK.ORCID 0000-0002-3781-0117
Simon PackerPublic Health England, 61 Colindale Ave, London, NW9 5EQ, UK.ORCID 0000-0002-9157-3650
Andrew J PageQuadram Institute Bioscience, Norwich Research Park, Norwich, NR4 7UQ, UK.ORCID 0000-0001-6919-6062
Marina MetaxakiUniversity of Cambridge, Department of Medicine, Cambridge, UK.ORCID 0000-0002-4552-1622
Stewart FullerUniversity of Cambridge, Department of Medicine, Cambridge, UK.
Gillian WealeHealth, Safety & Regulated Facilities Division, University of Cambridge, Cambridge, UK.ORCID 0000-0003-4728-5915
Jon HolgateUniversity Information Services, University of Cambridge, Cambridge, UK.
Christopher A BrownCambridge Covid-19 Testing Centre, Discovery Sciences, R&D, AstraZenenca, Cambridge, UK.ORCID 0000-0001-7773-0878
Cambridge Covid-19 testing Centre
University of Cambridge Asymptomatic COVID-19 Screening Programme Consortium
COVID-19 Genomics UK (COG-UK) Consortium
Rob HowesCambridge Covid-19 Testing Centre, Discovery Sciences, R&D, AstraZenenca, Cambridge, UK.
Duncan McFarlaneInstitute for Manufacturing, University of Cambridge, Cambridge, UK.
Gordon DouganUniversity of Cambridge, Department of Medicine, Cambridge, UK.
Oliver G PybusDepartment of Zoology, University of Oxford, Oxford, UK.ORCID 0000-0002-8797-2667
Daniela De AngelisPublic Health England, 61 Colindale Ave, London, NW9 5EQ, UK.
Patrick H MaxwellUniversity of Cambridge, Department of Medicine, Cambridge, UK.
Sharon J PeacockUniversity of Cambridge, Department of Medicine, Cambridge, UK.ORCID 0000-0002-1718-2782
Michael P WeekesCambridge University Hospital NHS Foundation Trust, Cambridge, UK.ORCID 0000-0003-3196-5545
Chris IllingworthMRC Biostatistics Unit, University of Cambridge, East Forvie Building, Forvie Site, Robinson Way, Cambridge, CB2 0SR, UK.
Ewan M HarrisonUniversity of Cambridge, Department of Medicine, Cambridge, UK. eh6@sanger.ac.uk.ORCID 0000-0003-2720-0507
Nicholas J MathesonUniversity of Cambridge, Department of Medicine, Cambridge, UK. njm25@cam.ac.uk.ORCID 0000-0002-3318-1851
Ian G GoodfellowUniversity of Cambridge, Department of Pathology, Division of Virology, Cambridge, UK. ig299@cam.ac.uk.ORCID 0000-0002-9483-510X
University of Cambridge · GBWellcome Sanger Institute · GBPublic Health England · GBPublic Health Wales · GBMRC University of Glasgow Centre for Virus Research · GBUniversity of Birmingham · GBUniversity of Liverpool · GBUniversity of Sheffield · GBUniversity of Oxford · GBCambridge University Hospitals NHS Foundation Trust · GBCardiff University · GBNorwich Research Park · GBUniversity of Nottingham · GBUniversity of Exeter · GBUniversity of Warwick · GBGuy's and St Thomas' NHS Foundation Trust · GBImperial College London · GBUniversity of Portsmouth · GBQueen's Medical Centre · GBUniversity College London · GB

Funding

Medical Research Council MC_PC_19026Medical Research Council MC_PC_19027Medical Research Council MC_UU_00002/11Medical Research Council MC_UU_12014/12Medical Research Council MR/N029399/1Medical Research Council MR/P008801/1Medical Research Council MR/S00291X/1Wellcome Trust 204911/Z/16/ZWellcome Trust (Wellcome) 222903/Z/21/Z
6 · The paper itself

Abstract

Understanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics.

Indexed as

UniversitiesContact TracingCOVID-19Genome, ViralGenomicsHumansPhylogenyRisk FactorsRNA, ViralSARS-CoV-2StudentsUnited KingdomRNA, Viral

Identifiers

PMID35136068
PMCPMC8826310
OpenAlexW4220681045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.