ArticleNature communications2022
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
- Trial
- Nutrient and non-nutrient regulators of insulin secretion.Nature reviews. Endocrinology · 2026Review
- Article
- Tomosyn-2 Regulates Postnatal β-Cell Expansion and Insulin Secretion to Maintain Glucose Homeostasis.Diabetes · 2026Article
- Development of Potential Pharmacological Targets to Normalize Gene Expression in Islets of Type 2 Diabetic Patients.Current medicinal chemistry · 2026Article
- Incorporation of gas/liquid equilibration control into a perifusion system to measure tissue-specific OAmerican journal of physiology. Cell physiology · 2025Article
- Placental mitochondrial calcium uniporter modulates offspring susceptibility to metabolic dysfunction.Molecular metabolism · 2025Article
- Effect of lipotoxic hepatocyte-derived extracellular vesicles in pancreas inflammation: essential role of macrophage TLR4 in beta cell functionality.Diabetologia · 2025Article
- Adipocyte RNF20 Knockout Leads to Hyperinsulinemia via the H2Bub-H3K4me3-Slc2a4 Axis.Journal of cellular and molecular medicine · 2025Article
- Unraveling the Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic Interventions.International journal of molecular sciences · 2025Review
- Identifying insulin-responsive circRNAs in chicken pectoralis.BMC genomics · 2025Article
- The interplay of factors in metabolic syndrome: understanding its roots and complexity.Molecular medicine (Cambridge, Mass.) · 2024Review
- A functional approach to homeostatic regulation.Biology direct · 2024Article
- An INSULIN and IAPP dual reporter enables tracking of functional maturation of stem cell-derived insulin producing cells.Molecular metabolism · 2024Article
- Insulin receptor isoform B is required for efficient proinsulin processing in pancreatic β cells.iScience · 2024Article
- Article
- β-Cell Insulin Resistance Plays a Causal Role in Fat-Induced β-Cell Dysfunction In Vitro and In Vivo.Endocrinology · 2024Article
- Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity.Nature metabolism · 2024Article
- The Regulation of Metabolic Homeostasis by Incretins and the Metabolic Hormones Produced by Pancreatic Islets.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Sex Differences in Pancreatic β-Cell Physiology and Glucose Homeostasis in C57BL/6J Mice.Journal of the Endocrine Society · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors at 6 institutions in 2 countries.
Søs SkovsøDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Evgeniy PanzhinskiyDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Jelena KolicDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0003-4151-1280
Haoning Howard CenDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0001-8045-1335
Derek A DionneDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Xiao-Qing DaiAlberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada.
Rohit B SharmaDivision of Endocrinology, Diabetes and Metabolism and the Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY, USA.
Lynda ElghaziDepartment of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor, MI, USA.
Cara E EllisDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Katharine FaulknerDepartment of Mathematics, University of British Columbia, Vancouver, BC, Canada.
Stephanie A M MarcilDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Peter OverbyDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Nilou NoursadeghiDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Daria HutchinsonDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Xiaoke HuDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Hong LiDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Honey ModiDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Jennifer S WildiDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
J Diego BotezelliDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Hye Lim NohProgram in Molecular Medicine University of Massachusetts Medical School, Worcester, MA, USA.
Sujin SukProgram in Molecular Medicine University of Massachusetts Medical School, Worcester, MA, USA.
Brian GablaskiDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Austin BautistaAlberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada.
Ryekjang KimAlberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada.
Corentin Cras-MéneurDepartment of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-8921-8927
Stephane FlibotteUBC Life Sciences Institute Bioinformatics Facility, University of British Columbia, Vancouver, BC, Canada.
Sunita SinhaUBC Sequencing and Bioinformatics Consortium, Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
Dan S LucianiBC Children's Hospital Research Institute, Department of Surgery, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Corey NislowUBC Sequencing and Bioinformatics Consortium, Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0002-4016-8874
Elizabeth J RideoutDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Eric N CytrynbaumDepartment of Mathematics, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0001-8789-1667
Jason K KimProgram in Molecular Medicine University of Massachusetts Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-7185-042X
Ernesto Bernal-MizrachiDivision of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine and Miami VA Health Care System, Miami, FL, USA.
Laura C AlonsoDivision of Endocrinology, Diabetes and Metabolism and the Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-5056-8970
Patrick E MacDonaldAlberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada.
James D JohnsonDiabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada. James.d.johnson@ubc.ca.ORCID http://orcid.org/0000-0002-7523-9433
University of British Columbia · CAUniversity of Alberta · CAUniversity of Massachusetts Chan Medical School · USCornell University · USUniversity of Michigan · USUniversity of Miami Health System · US
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLIAM H HERMAN · 2013 to 2026
$24.3MAKT/mTOR Signaling and Regulation of Cell Cycle in beta CellsR01DK073716 · NIDDK · WASHINGTON UNIVERSITY · PI BERNAL-MIZRACHI, ERNESTO · 2006 to 2022
$4.6MUMass Mouse Metabolic Phenotyping Center - Metabolism CoreU2CDK093000 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2016 to 2021
$4.6MUMass Mouse Metabolic Phenotyping CenterU24DK093000 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2011 to 2015
$2.1MATF6 and the Beta CellR01DK114686 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ALONSO, LAURA C · 2017 to 2019
$1.5MmTOR signaling and regulation of alpha-cell mass and functionI01BX002728 · VA · MIAMI VA HEALTH CARE SYSTEM · PI BERNAL-MIZRACHI, ERNESTO · 2016 to 2025
–BLRD VA I01 BX002728NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK073716NIDDK NIH HHS R01 DK114686NIDDK NIH HHS U24 DK093000NIDDK NIH HHS U2C DK093000
Abstract
Insulin receptor (Insr) protein is present at higher levels in pancreatic β-cells than in most other tissues, but the consequences of β-cell insulin resistance remain enigmatic. Here, we use an Ins1
Indexed as
AnimalsDatasets as TopicDiabetes Mellitus, Type 2Diet, High-FatDisease Models, AnimalFemaleGene Knock-In TechniquesGene Knockout TechniquesGlucoseHumansHyperinsulinismInsulinInsulin ResistanceInsulin-Secreting CellsMaleMiceGlucoseInsulinReceptor, Insulin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.