ArticleNature communications2022
Hippocampal ensembles represent sequential relationships among an extended sequence of nonspatial events.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- A novel rat spatial inference task reveals rapid deduction of transitive relationships using schemas and deliberation.Behavioral neuroscience · 2026Article
- The hippocampus rapidly integrates sequence representations during novel multistep predictions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- The hippocampal CA3 area implements sequence learning of discontinuous episodes.Communications biology · 2026Article
- Hippocampal conditioning code dominates and disrupts the place code.bioRxiv : the preprint server for biology · 2026Article
- Neurodatascience: Past, Present, and Future.Data science in science · 2026Article
- Neural Representation of Episodic Time.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Optimal Transport based Cross-Domain Integration for Heterogeneous Data.Journal of the American Statistical Association · 2025Article
- The Hippocampus Rapidly Integrates Sequence Representations During Novel Multistep Predictions.bioRxiv : the preprint server for biology · 2025Article
- A scalable reinforcement learning framework inspired by hippocampal memory mechanisms for efficient contextual and sequential decision making.Scientific reports · 2025Article
- A flexible hippocampal population code for experience relative to reward.Nature neuroscience · 2025Article
- The human medial temporal lobe represents memory items in their ordinal position in both declarative and motor memory domains.PLoS biology · 2025Article
- A Model-Agnostic Graph Neural Network for Integrating Local and Global Information.Journal of the American Statistical Association · 2025Article
- Targeting MAD2B as a strategy for ischemic stroke therapy.Journal of advanced research · 2025Article
- Learning Temporal Relationships Between Symbols with Laplace Neural Manifolds.Computational brain & behavior · 2025Article
- Attention to memory content enhances single-unit spike sequence fidelity in the human anterior temporal lobe.Current biology : CB · 2025Article
- The influence of emotion on temporal context models.Cognition & emotion · 2025Review
- The Gaussian-linear hidden Markov model: A Python package.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Hippocampal and orbitofrontal neurons contribute to complementary aspects of associative structure.Nature communications · 2024Article
- Selection of experience for memory by hippocampal sharp wave ripples.Science (New York, N.Y.) · 2024Article
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Authors and funding
9 authors.
Funding
Abstract
The hippocampus is critical to the temporal organization of our experiences. Although this fundamental capacity is conserved across modalities and species, its underlying neuronal mechanisms remain unclear. Here we recorded hippocampal activity as rats remembered an extended sequence of nonspatial events unfolding over several seconds, as in daily life episodes in humans. We then developed statistical machine learning methods to analyze the ensemble activity and discovered forms of sequential organization and coding important for order memory judgments. Specifically, we found that hippocampal ensembles provide significant temporal coding throughout nonspatial event sequences, differentiate distinct types of task-critical information sequentially within events, and exhibit theta-associated reactivation of the sequential relationships among events. We also demonstrate that nonspatial event representations are sequentially organized within individual theta cycles and precess across successive cycles. These findings suggest a fundamental function of the hippocampal network is to encode, preserve, and predict the sequential order of experiences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.