ArticleCell death & disease2022
Targeted activation of androgen receptor signaling in the periosteum improves bone fracture repair.
Article in Cell death & disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Sex hormones and their receptors in osteoarthritis: current research progress.Annals of joint · 2026Review
- Local estradiol deposition in a rat rotator cuff repair model: proof of concept.JSES international · 2025Article
- Callus organoids reveal distinct cartilage to bone transition mechanisms across donors and a role for biological sex.Bone research · 2025Article
- CD90's role in vascularization and healing of rib fractures: insights from Dll4/notch regulation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Identification of Postn+ periosteal progenitor cells with bone regenerative potential.JCI insight · 2024Article
- Ilizarov Distraction for Congenital Pseudoarthrosis of the Tibia in Adults.Orthopaedic surgery · 2024Article
- GBA1 as a risk gene for osteoporosis in the specific populations and its role in the development of Gaucher disease.Orphanet journal of rare diseases · 2024Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
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Abstract
Low testosterone level is an independent predictor of osteoporotic fracture in elderly men as well as increased fracture risk in men undergoing androgen deprivation. Androgens and androgen receptor (AR) actions are essential for bone development and homeostasis but their linkage to fracture repair remains unclear. Here we found that AR is highly expressed in the periosteum cells and is co-localized with a mesenchymal progenitor cell marker, paired-related homeobox protein 1 (Prrx1), during bone fracture repair. Mice lacking the AR gene in the periosteum expressing Prrx1-cre (AR
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