ArticleTranslational psychiatry2022
Social support mediates the influence of cerebellum functional connectivity strength on postpartum depression and postpartum depression with anxiety.
Article in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Neural correlates of peripartum depression: a systematic review, meta-analysis and comparison to major depressive disorder.Molecular psychiatry · 2025Pooled it
- Neural substrates of reward anticipation and outcome in schizophrenia: a meta-analysis of fMRI findings in the monetary incentive delay task.Translational psychiatry · 2022Pooled it
- Structural, functional, and metabolic signatures of postpartum depression: A systematic review.Frontiers in psychiatry · 2022Pooled it
- Cerebral blood flow alterations in non-auditory tinnitus: implications for cerebral venous congestion pathophysiology.Brain imaging and behavior · 2026Article
- Mapping neurophysiological biotypes of postpartum depression and underlying neural and molecular basis.Communications medicine · 2026Article
- Prevalence and risk factors of postpartum depression, anxiety, and comorbidity of both disorders: a cross-sectional study.BMC pregnancy and childbirth · 2025Article
- Social support and depressive symptoms: the role of childhood maltreatment and brain activity in a moderated mediation model.Social cognitive and affective neuroscience · 2025Article
- Cerebellar MRI-based radiomics models for identifying mild cognitive impairment: a retrospective multicenter study in Southeast China.Frontiers in aging neuroscience · 2025Article
- The association between social support and postpartum post-traumatic stress disorder.BMC pregnancy and childbirth · 2024Article
- Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety.Nature communications · 2024Article
- Molecular basis underlying changes of brain entropy and functional connectivity in major depressive disorders after electroconvulsive therapy.CNS neuroscience & therapeutics · 2024Article
- Personalized functional network mapping for autism spectrum disorder and attention-deficit/hyperactivity disorder.Translational psychiatry · 2024Article
- Aberrant resting-state co-activation network dynamics in major depressive disorder.Translational psychiatry · 2024Article
- Functional connectivity alterations in the thalamus among patients with bronchial asthma.Frontiers in neurology · 2024Article
- Mediation role of anxiety on social support and depression among diabetic patients in elderly caring social organizations in China during COVID-19 pandemic: a cross-sectional study.BMC geriatrics · 2023Article
- LRFN5 and OLFM4 as novel potential biomarkers for major depressive disorder: a pilot study.Translational psychiatry · 2023Article
- Structural and functional changes in drug-naïve benign childhood epilepsy with centrotemporal spikes and their associated gene expression profiles.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The role of ascending arousal network in patients with chronic insomnia disorder.Human brain mapping · 2023Article
- Aberrant structural and functional alterations in postpartum depression: a combined voxel-based morphometry and resting-state functional connectivity study.Frontiers in neuroscience · 2023Article
- Prediction of childhood maltreatment and subtypes with personalized functional connectome of large-scale brain networks.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-Partum Depression (PPD) is the most common health issue impacting emotional well being in women and is often comorbid with anxiety (PPD-A). Previous studies have shown that adequate social support can protect against PPD and PPD-A. However, how the brain connectome is disrupted in PPD and PPD-A and the neural basis underlying the role of social support in PPD and PPD-A remains unclear. The present study aims to explore these issues in patients with PPD and PPD-A. Well-established questionnaires and resting-state functional Magnetic Resonance Imaging (rsfMRI) were performed in 45 PPD, 31 PDD-A patients and 62 Healthy Postnatal Women (HPW). Brain functional integration was measured by analysis of Functional Connectivity Strength (FCS). Association and mediation analyses were performed to investigate relationships between FCS, PPD and PPD-A symptoms and social support. PPD patients showed specifically higher FCS in right parahippocampus, whereas PPD-A patients showed specifically higher FCS in left ventrolateral prefrontal cortex. In all postpartum women, depression symptoms positively correlated with FCS in left paracentral lobule; depression and anxiety symptoms were negatively correlated with FCS in right cerebellem posterior lobe (CPL), a brain region implicated in supporting social cognition and regulation of emotion. Subsequent mediation analysis revealed that perceived social support mediated the association between right CPL FCS and PPD and PPD-A symptoms. Measurement of FCS in disorder-specific neural circuits offers a potential biomarker to study and measure the efficacy of social support for PPD and PPD-A.
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