ArticleThe Journal of veterinary medical science2022
Recommended doses of medetomidine-midazolam-butorphanol with atipamezole for preventing hypothermia in mice.
Article in The Journal of veterinary medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Nicardipine co-administered with medetomidine-midazolam-butorphanol anesthesia attenuates post-anesthetic hypothermia in rats.Experimental animals · 2026Article
- Radial pressure wave treatment accelerates recovery from immobilization-induced soleus muscle atrophy and improves ankle range of motion in mice.European journal of applied physiology · 2026Article
- Evaluation of the efficacy and safety of a modified anesthetic protocol using dexmedetomidine, midazolam, and butorphanol in mice.The Journal of veterinary medical science · 2026Article
- Goreisan-mediated suppression of chemokine and cytokine production in astrocytes under AQP4-expressing conditions.Frontiers in neuroscience · 2026Article
- Evaluation of a modified triple-combination anesthesia using dexmedetomidine in mice.Animal models and experimental medicine · 2025Article
- Dual-route medetomidine-alfaxalone-butorphanol anesthesia: a refined protocol for balanced anesthesia in male rabbits.Experimental animals · 2025Article
- In vivo flavoprotein functional imaging of the mouse auditory cortex combined with neuroanatomical tracing.Anatomical science international · 2025Article
- Dual-route administration of balanced anesthesia using medetomidine, midazolam, and butorphanol provides both suitable anesthetic depth and reduced tissue injury in rabbits.Experimental animals · 2025Article
- Combined medetomidine, midazolam, and butorphanol anesthesia in mice has a central stress-relieving effect similar to that of isoflurane anesthesia.The Journal of veterinary medical science · 2025Article
- Optimization of inhaled anesthesia for Octodon degus using electroencephalography.Experimental animals · 2025Article
- Molecular mechanisms driving the interactions between platelet and gastric cancer cells during peritoneal dissemination.Oncology letters · 2024Article
- Validation of the anesthetic effect of a mixture of remimazolam, medetomidine, and butorphanol in three mouse strains.Experimental animals · 2024Article
- Induction of lung lesions by bronchial administration using bronchoscope technique in mice.Journal of toxicologic pathology · 2024Article
- Evaluation of general anesthesia protocols for a highly controlled cardiac ischemia-reperfusion model in mice.PloS one · 2024Article
- Medetomidine/midazolam/fentanyl narcosis alters cardiac autonomic tone leading to conduction disorders and arrhythmias in mice.Lab animal · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A non-narcotic anesthetic combination (Me/Mi/Bu) of medetomidine (Me), midazolam (Mi), and butorphanol (Bu) has been recommended as the injectable anesthesia in mice. An original dose of Me/Mi/Bu (0.3/4.0/5.0 mg/kg) has provided sufficient anesthetic duration of 40-50 min in mice. In addition, atipamezole is available for reversal of Me/Mi/Bu anesthesia. As an adverse effect of Me/Mi/Bu anesthesia, however, severe hypothermia has been also observed in mice. In the present study, we investigated 1) the main agent in Me/Mi/Bu to cause of hypothermia, 2) the effects of the differential doses of atipamezole on hypothermia induced by Me/Mi/Bu anesthesia and on the plasma levels of creatinine phosphokinase and transaminases, and 3) those recommended doses for preventing hypothermia induced by Me/Mi/Bu anesthesia in mice. The results suggested that 1) the α
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