Evidence map›Paper›PMID 35135929›Full record

ArticleInternal medicine (Tokyo, Japan)2022

New-onset Type 1 Diabetes after COVID-19 mRNA Vaccination.

Masahiro Yano, Tomoaki Morioka, Yuka Natsuki, Keyaki Sasaki, Yoshinori Kakutani, Akinobu Ochi, Yuko Yamazaki, Tetsuo Shoji, Masanori Emoto

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  9. An overview of HLA variants in COVID-19 vaccine-induced autoimmunity.International journal of molecular epidemiology and genetics · 2025
    Review
  10. Article
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  13. Article
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  15. Article
  16. Internal Medicine Year in Review 2022.Internal medicine (Tokyo, Japan) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Masahiro YanoDepartment of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan.
Tomoaki MoriokaDepartment of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan.
Yuka NatsukiDepartment of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan.
Keyaki SasakiDepartment of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan.
Yoshinori KakutaniDepartment of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan.
Akinobu OchiDepartment of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan.
Yuko YamazakiDepartment of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan.
Tetsuo ShojiDepartment of Vascular Medicine, Osaka City University Graduate School of Medicine, Japan.
Masanori EmotoDepartment of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan.
Osaka City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the ongoing coronavirus disease 2019 (COVID-19) pandemic, it is critical to ensure the safety of COVID-19 vaccines. We herein report a 51-year-old Japanese woman who developed acute-onset type 1 diabetes with diabetic ketoacidosis six weeks after receiving the first dose of a COVID-19 messenger ribonucleic acid (mRNA) vaccine. Laboratory tests indicated exhaustion of endogenous insulin secretion, a positive result for insulin autoantibody, and latent thyroid autoimmunity. Human leukocyte antigen typing was homozygous for DRB1*09:01-DQB1*03:03 haplotypes. This case suggests that COVID-19 vaccination can induce type 1 diabetes in some individuals with a genetic predisposition.

Indexed as

COVID-19Diabetes Mellitus, Type 1COVID-19 VaccinesFemaleHumansMiddle AgedRNA, MessengerVaccinationCOVID-19 VaccinesRNA, MessengerautoimmunityCOVID-19hyperglycemiamRNA vaccineSARS-CoV-2type 1 diabetes

Identifiers

PMID35135929
PMCPMC9107966
OpenAlexW4210841610

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.