Evidence map›Paper›PMID 35135875›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Disrupted

Erik Smedler, Lauri Louhivuori, Roman A Romanov, Débora Masini, Ivar Dehnisch Ellström, Chungliang Wang, Martino Caramia, Zoe West, Songbai Zhang, Paola Rebellato and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Reinventing amlodipine.The Journal of pharmacology and experimental therapeutics · 2026
    Review
  2. Article
  3. Epigenomic profile of GBA1 in Parkinson's disease.Parkinsonism & related disorders · 2025
    Article
  4. Article
  5. Structure of a polymorphic repeat at theProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. The Impact of Overexpression of the Mouse Ortholog ofBiological psychiatry global open science · 2025
    Article
  7. Structure of a polymorphic repeat at themedRxiv : the preprint server for health sciences · 2025
    Article
  8. Reduced Gene Dosage of the Psychiatric Risk GeneInternational journal of molecular sciences · 2025
    Article
  9. Article
  10. Article
  11. L-methionine and the L-type CaFrontiers in neural circuits · 2024
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Erik SmedlerDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-17177, Sweden; erik.smedler@gu.se per.uhlen@ki.se.
Lauri LouhivuoriDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-17177, Sweden.
Roman A RomanovDepartment of Neuroscience, Karolinska Institutet, Stockholm SE-17177, Sweden.
Débora MasiniDepartment of Neuroscience, Karolinska Institutet, Stockholm SE-17177, Sweden.ORCID 0000-0003-1467-2388
Ivar Dehnisch EllströmDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-17177, Sweden.ORCID 0000-0002-0577-1192
Chungliang WangDepartment of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, Huddinge SE-14152, Sweden.
Martino CaramiaDepartment of Neuroscience, Karolinska Institutet, Stockholm SE-17177, Sweden.
Zoe WestDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-17177, Sweden.
Songbai ZhangDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-17177, Sweden.ORCID 0000-0002-2033-8389
Paola RebellatoDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-17177, Sweden.
Seth MalmersjöDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-17177, Sweden.ORCID 0000-0002-1519-8916
Irene BrusiniDepartment of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, Huddinge SE-14152, Sweden.ORCID 0000-0003-3479-4243
Shigeaki KanataniDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-17177, Sweden.
Gilberto FisoneDepartment of Neuroscience, Karolinska Institutet, Stockholm SE-17177, Sweden.ORCID 0000-0002-0719-8000
Tibor HarkanyDepartment of Neuroscience, Karolinska Institutet, Stockholm SE-17177, Sweden.ORCID 0000-0002-6637-5900
Per UhlénDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-17177, Sweden; erik.smedler@gu.se per.uhlen@ki.se.ORCID 0000-0003-1446-1062
Karolinska Institutet · SEKTH Royal Institute of Technology · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The L-type voltage-gated Ca

Indexed as

AnimalsAnxiety DisordersBiological ClocksBrainCalciumCalcium Channels, L-TypeGene Expression Regulation, DevelopmentalGenetic Predisposition to DiseaseMiceMice, KnockoutNeural Stem CellsCACNA1C protein, mouseCalciumCalcium Channels, L-Typeanxietybrain developmentCacna1ccalcium signalingpsychiatric disorders

Identifiers

PMID35135875
PMCPMC8851547
OpenAlexW4210898293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.