Evidence map›Paper›PMID 35135874›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Nitric oxide stimulates type IV MSHA pilus retraction in

Hannah Q Hughes, Kyle A Floyd, Sajjad Hossain, Sweta Anantharaman, David T Kysela, Miklόs Zöldi, Lászlό Barna, Yuanchen Yu, Michael P Kappler, Triana N Dalia and 10 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Structural modeling reveals the mechanism of motor ATPase coordination during type IV pilus retraction.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Nitric oxide promotes rapid development of motility to accelerate biofilm dispersal inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Genomic Insight intoPathogens (Basel, Switzerland) · 2025
    Article
  7. Review
  8. Shear force enhances adhesion ofProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Review
  10. Article
  11. Review
  12. Shear force enhances adhesion ofbioRxiv : the preprint server for biology · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 2 countries.

Hannah Q HughesDepartment of Biology, Indiana University, Bloomington, IN 47405.ORCID 0000-0002-8335-2612
Kyle A FloydDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA 95064.
Sajjad HossainDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794.
Sweta AnantharamanDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794.
David T KyselaDepartment of Microbiology, Infectious Diseases, and Immunology, Université de Montréal, Montréal, QC H3T 1J4, Canada.
Miklόs ZöldiDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.ORCID 0000-0002-8592-5015
Lászlό BarnaDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.ORCID 0000-0002-3856-5774
Yuanchen YuDepartment of Chemistry, Indiana University, Bloomington, IN 47405.
Michael P KapplerDepartment of Chemistry, Indiana University, Bloomington, IN 47405.
Triana N DaliaDepartment of Biology, Indiana University, Bloomington, IN 47405.
Ram C PodichetiCenter for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405.
Douglas B RuschCenter for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405.ORCID 0000-0002-1066-2687
Meng ZhuangDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904.
Cassandra L FraserDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904.
Yves V BrunDepartment of Microbiology, Infectious Diseases, and Immunology, Université de Montréal, Montréal, QC H3T 1J4, Canada.
Stephen C JacobsonDepartment of Chemistry, Indiana University, Bloomington, IN 47405.ORCID 0000-0003-2415-041X
James B McKinlayDepartment of Biology, Indiana University, Bloomington, IN 47405.ORCID 0000-0003-2401-6229
Fitnat H YildizDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA 95064.
Elizabeth M BoonDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794.
Ankur B DaliaDepartment of Biology, Indiana University, Bloomington, IN 47405; ankdalia@indiana.edu.ORCID 0000-0003-2203-1230
Indiana University Bloomington · USStony Brook University · USUniversité de Montréal · CAUniversity of California, Santa Cruz · USUniversity of Virginia · US

Funding

Vibrio cholerae c-diGMP signaling: Motile to biofilm transition and transmissionR01AI102584 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI YILDIZ, HAVVA FITNAT · 2013 to 2023
$6.5M
Mechanisms and regulation of horizontal gene transfer by natural transformation in Vibrio choleraeR35GM128674 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Ankur Dalia · 2018 to 2026
$3.8M
The role of NosP in Pseudomonas aeruginosa biofilm developmentR01GM118894 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI ELIZABETH M BOON · 2017 to 2026
$3.0M
Chemical Biology Training InterfaceT32GM136572 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI ELIZABETH M BOON, Jessica Chuang Seeliger · 2020 to 2026
$2.9M
Luminescent Oxygen Nanosensors for Tumor Hypoxia ImagingR01CA167250 · NCI · UNIVERSITY OF VIRGINIA · PI FRASER, CASSANDRA L · 2012 to 2016
$1.7M
Microfluidic Devices for Studying the Development and Aging of BacteriaR01GM113121 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI JACOBSON, STEPHEN C · 2016 to 2019
$1.1M
NCI NIH HHS R01 CA167250NIAID NIH HHS R01 AI102584NIGMS NIH HHS R01 GM113121NIGMS NIH HHS R01 GM118894NIGMS NIH HHS R35 GM128674NIGMS NIH HHS T32 GM136572
6 · The paper itself

Abstract

Bacteria use surface appendages called type IV pili to perform diverse activities including DNA uptake, twitching motility, and attachment to surfaces. The dynamic extension and retraction of pili are often required for these activities, but the stimuli that regulate these dynamics remain poorly characterized. To address this question, we study the bacterial pathogen

Indexed as

Bacterial AdhesionFimbriae, BacterialFimbriae ProteinsGene Expression Regulation, BacterialNitric OxideVibrio choleraeFimbriae ProteinsNitric Oxideattachmentbiofilmtype IV pili

Identifiers

PMID35135874
PMCPMC8851539
OpenAlexW4210943713

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.