ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Ipsilateral Stimulus Encoding in Primary and Secondary Somatosensory Cortex of Awake Mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Reduced inhibition, bursting, and accelerated oscillations drive early hippocampal hyperactivity in Alzheimer's disease in vivo.Communications biology · 2026Article
- An intralayer microcircuit in the temporal association cortex underlies sensory-induced escape in mice.Nature communications · 2026Article
- Functional and structural neuroplasticity of somatosensory system in hemiplegic cerebral palsy.Brain communications · 2026Article
- Alpha Modulation of Spiking Activity Across Multiple Brain Regions in Mice Performing a Tactile Selective Detection Task.The European journal of neuroscience · 2025Article
- Layer 6 Corticothalamic Neurons Induce High Gamma Oscillations Through Cortico-cortical and Cortico-thalamo-cortical Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Bilateral integration in somatosensory cortex is controlled by behavioral relevance.Nature neuroscience · 2025Article
- Intra-somatosensory cortical circuits mediating pain-induced analgesia.Nature communications · 2025Article
- Resting-state functional connectivity changes following audio-tactile speech training.Frontiers in neuroscience · 2025Article
- Non-invasive 4D transcranial functional ultrasound and ultrasound localization microscopy for multimodal imaging of neurovascular response.Scientific reports · 2024Article
- A latent pool of neurons silenced by sensory-evoked inhibition can be recruited to enhance perception.Neuron · 2024Article
- Representation of rhythmic chunking in striatum of mice executing complex continuous movement sequences.Cell reports · 2024Article
- Stimulus information guides the emergence of behavior-related signals in primary somatosensory cortex during learning.Cell reports · 2024Article
- Dynamic corticothalamic modulation of the somatosensory thalamocortical circuit during wakefulness.Nature communications · 2024Article
- The secondary somatosensory cortex gates mechanical and heat sensitivity.Nature communications · 2024Article
- A machine learning approach for real-time cortical state estimation.Journal of neural engineering · 2024Article
- Interareal Synaptic Inputs Underlying Whisking-Related Activity in the Primary Somatosensory Barrel Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Latent dynamics of primary sensory cortical population activity structured by fluctuations in the local field potential.Frontiers in computational neuroscience · 2024Article
- Callosal inputs generate side-invariant receptive fields in the barrel cortex.Science advances · 2023Article
- Motor cortex gates distractor stimulus encoding in sensory cortex.Nature communications · 2023Article
- Cognitive and affective interaction with somatosensory afference in acupuncture-a specific brain response to compound stimulus.Frontiers in human neuroscience · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Lateralization is a hallmark of somatosensory processing in the mammalian brain. However, in addition to their contralateral representation, unilateral tactile stimuli also modulate neuronal activity in somatosensory cortices of the ipsilateral hemisphere. The cellular organization and functional role of these ipsilateral stimulus responses in awake somatosensory cortices, especially regarding stimulus coding, are unknown. Here, we targeted silicon probe recordings to the vibrissa region of primary (S1) and secondary (S2) somatosensory cortex of awake head-fixed mice of either sex while delivering ipsilateral and contralateral whisker stimuli. Ipsilateral stimuli drove larger and more reliable responses in S2 than in S1, and activated a larger fraction of stimulus-responsive neurons. Ipsilateral stimulus-responsive neurons were rare in layer 4 of S1, but were located in equal proportion across all layers in S2. Linear classifier analyses further revealed that decoding of the ipsilateral stimulus was more accurate in S2 than S1, whereas S1 decoded contralateral stimuli most accurately. These results reveal substantial encoding of ipsilateral stimuli in S1 and especially S2, consistent with the hypothesis that higher cortical areas may integrate tactile inputs across larger portions of space, spanning both sides of the body.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.