ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 114 citations in OpenAlex.
- Cardiovascular Responses to Natural and Auditory Evoked Slow Waves Predict Post-Sleep Cardiac Function.Journal of sleep research · 2026Trial
- Sleep deprivation and sleep intensity exert distinct effects on cerebral vasomotion and brain pulsations driven by the respiratory and cardiac cycles.PLoS biology · 2025Trial
- The glymphatic-lymphatic axis: known pathways, open questions, and emerging roles in neurodegeneration.Translational neurodegeneration · 2026Review
- How brain pulsations drive solute transport in the cranial subarachnoid space: insights from a toy model.Journal of the Royal Society, Interface · 2026Article
- The Role of Glymphatic Clearance in Affective Decision-Making in Adolescents with Non-Suicidal Self-Injury.CNS neuroscience & therapeutics · 2026Article
- Glymphatic system dysfunction: a link between sleep disorders and neurodegeneration.Psychopharmacology · 2026Review
- Inhibitory Decay and Supercritical Brain Dynamics During Sleep Deprivation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Kidney-Brain Axis in Chronic Kidney Disease: Uremic Toxins, Cognitive Decline, Mechanistic Pathways, Biomarkers and Therapeutic Perspectives.Biomedicines · 2026Review
- Infra-slow (<0.1 Hz) Modulation of Human Brain Pulsations in Awake and Sleep States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Greater hypoxic burden predicts weaker coordination between brain pulsation and CSF flow on 7T MRI independent of non-hypoxic arousals: Implications for glymphatic activity.bioRxiv : the preprint server for biology · 2026Article
- Sleep Alters the Velocity of Physiological Brain Pulsations in Humans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Sleep alters neurovascular and hydrodynamic coupling in the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Regulation of Vasomotor and Cardiorespiratory Pulsations Is Disrupted in Primary Central Nervous System Lymphoma: A Case-Control fMRI Study.Human brain mapping · 2026Article
- Brain Pulsation Imaging Using Non-Balanced Steady-State Free Precession With 3D-EPI Readout.Magnetic resonance in medicine · 2026Article
- Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals.Nature neuroscience · 2026Article
- Regional and network patterns of sleep-depth-associated brain diffusion changes: an EEG-informed multishell diffusion MRI study.Frontiers in neuroscience · 2026Article
- A user's introduction to an algorithmic method to identify space-time profiles of sleep slow oscillations: dataset constraints, case-use examples, and open-source code.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Effect of organismal rhythmic activity on Aβ clearance by the glymphatic system.European journal of medical research · 2025Review
12 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors at 3 institutions in 3 countries.
Funding
Abstract
The physiological underpinnings of the necessity of sleep remain uncertain. Recent evidence suggests that sleep increases the convection of cerebrospinal fluid (CSF) and promotes the export of interstitial solutes, thus providing a framework to explain why all vertebrate species require sleep. Cardiovascular, respiratory and vasomotor brain pulsations have each been shown to drive CSF flow along perivascular spaces, yet it is unknown how such pulsations may change during sleep in humans. To investigate these pulsation phenomena in relation to sleep, we simultaneously recorded fast fMRI, magnetic resonance encephalography (MREG), and electroencephalography (EEG) signals in a group of healthy volunteers. We quantified sleep-related changes in the signal frequency distributions by spectral entropy analysis and calculated the strength of the physiological (vasomotor, respiratory, and cardiac) brain pulsations by power sum analysis in 15 subjects (age 26.5 ± 4.2 years, 6 females). Finally, we identified spatial similarities between EEG slow oscillation (0.2-2 Hz) power and MREG pulsations. Compared with wakefulness, nonrapid eye movement (NREM) sleep was characterized by reduced spectral entropy and increased brain pulsation intensity. These effects were most pronounced in posterior brain areas for very low-frequency (≤0.1 Hz) vasomotor pulsations but were also evident brain-wide for respiratory pulsations, and to a lesser extent for cardiac brain pulsations. There was increased EEG slow oscillation power in brain regions spatially overlapping with those showing sleep-related MREG pulsation changes. We suggest that reduced spectral entropy and enhanced pulsation intensity are characteristic of NREM sleep. With our findings of increased power of slow oscillation, the present results support the proposition that sleep promotes fluid transport in human brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.