Evidence map›Paper›PMID 35135496›Full record

ArticleBMC infectious diseases2022

Persistent, new-onset symptoms and mental health complaints in Long COVID in a Brazilian cohort of non-hospitalized patients.

Ricardo Titze-de-Almeida, Thaylise Ramalho da Cunha, Letícia Dias Dos Santos Silva, Clarisse Santos Ferreira, Caroline Pena Silva, Adriana Pinheiro Ribeiro, Agenor de Castro Moreira Santos Júnior, Pedro Renato de Paula Brandão, Andrezza Paula Brito Silva, Márcia Cristina Oliveira da Rocha and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 7 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 7 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Global prevalence of post-COVID-19 condition: a systematic review and meta-analysis of prospective evidence.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2025
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Comparison of Long COVID-19 Caused by Different SARS-CoV-2 Strains: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
  8. Trial
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Ricardo Titze-de-AlmeidaResearch Center for Major Themes, University of Brasília-Central Institute of Sciences, Brasília, Brazil. ricardotitze.unb@gmail.com.ORCID http://orcid.org/0000-0002-5019-4742
Thaylise Ramalho da CunhaResearch Center for Major Themes, University of Brasília-Central Institute of Sciences, Brasília, Brazil.
Letícia Dias Dos Santos SilvaResearch Center for Major Themes, University of Brasília-Central Institute of Sciences, Brasília, Brazil.
Clarisse Santos FerreiraResearch Center for Major Themes, University of Brasília-Central Institute of Sciences, Brasília, Brazil.
Caroline Pena SilvaResearch Center for Major Themes, University of Brasília-Central Institute of Sciences, Brasília, Brazil.
Adriana Pinheiro RibeiroArmed Forces Hospital, Learning and Research Technical Board, Brasília, Brazil.
Agenor de Castro Moreira Santos JúniorCentral Laboratory of Public Health of the Federal District, Brasília, Brazil.
Pedro Renato de Paula BrandãoResearch Center for Major Themes, University of Brasília-Central Institute of Sciences, Brasília, Brazil.
Andrezza Paula Brito SilvaResearch Center for Major Themes, University of Brasília-Central Institute of Sciences, Brasília, Brazil.
Márcia Cristina Oliveira da RochaFederal District Strategic Health Management Institute, Brasília, Brazil.
Mary-Ann Elvina XavierResearch Center for Major Themes, University of Brasília-Central Institute of Sciences, Brasília, Brazil.
Simoneide Souza Titze-de-AlmeidaResearch Center for Major Themes, University of Brasília-Central Institute of Sciences, Brasília, Brazil.
Helena Eri ShimizuDepartment of Collective Health, Research Center for Major Themes, University of Brasília, Brasília, Brazil.
Raimundo Nonato Delgado-RodriguesResearch Center for Major Themes, University of Brasília-Central Institute of Sciences, Brasília, Brazil.
Universidade de Brasília · BRCentral Bank of Brazil · BR

Funding

Ministério da Educação TED/MEC n. 9249
6 · The paper itself

Abstract

backgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections lead to acute- and chronic Long COVID (LC) symptoms. However, few studies have addressed LC sequelae on brain functions. This study was aimed to examine if acute symptoms of coronavirus disease 2019 (COVID-19) would persist during LC, and if memory problems would be correlated with sleep, depressive mood, or anxious complaints.

methodsOur work followed a cohort of 236 patients from two public hospitals of the Federal District in mid-western Brazil. Patients' interviews checked for clinical symptoms during acute and LC (5-8 months after real-time reverse transcription polymerase chain reaction, RT-qPCR).

resultsMost cases were non-hospitalized individuals (86.3%) with a median age of 41.2 years. While myalgia (50%), hyposmia (48.3%), and dysgeusia (45.8%) were prevalent symptoms in acute phase, fatigue (21.6%) followed by headache (19.1%) and myalgia (16.1%) commonly occurred during LC. In LC, 39.8% of individuals reported memory complaints, 36.9% felt anxious, 44.9% felt depressed, and 45.8% had sleep problems. Furthermore, memory complaints were associated with sleep problems (adjusted OR 3.206; 95% CI 1.723-6.030) and depressive feelings (adjusted OR 3.981; 95% CI 2.068-7.815).

conclusionsThe SARS-CoV-2 infection leads to persistent symptoms during LC, in which memory problems may be associated with sleep and depressive complaints.

Indexed as

COVID-19Mental HealthAdultAnxietyBrazilDepressionHumansMemoryPost-Acute COVID-19 SyndromeBrazilCOVID-19DepressionLong COVIDMemorySleep

Identifiers

PMID35135496
PMCPMC8821794
OpenAlexW4210910735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.