Trial reportStroke2022
Improvements in Endovascular Treatment for Acute Ischemic Stroke: A Longitudinal Study in the MR CLEAN Registry.
Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Bridging thrombolysis versus direct thrombectomy in acute ischemic stroke with large vessel occlusion: a network meta-analysis.Journal of neurology · 2025Pooled it
- Trial
- Quality Improvement Intervention for Reducing Acute Treatment Times in Ischemic Stroke: A Cluster Randomized Clinical Trial.JAMA neurology · 2025Trial
- Number of Retrieval Attempts and the Association of Intravenous Tirofiban with Symptomatic Intracranial Hemorrhage in Patients with Successful Endovascular Therapy: Results of the RESCUE BT Trial.Clinical interventions in aging · 2024Trial
- Construction and Validation of a 90-Day Mortality Risk Prediction Model Based on Interpretable Machine Learning for Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy.Journal of clinical medicine · 2026Article
- Real-world effectiveness of thrombectomy for basilar artery occlusion: lessons beyond the ATTENTION and BAOCHE trials.European stroke journal · 2026Article
- Enhancing stroke care in Europe: cost-effectiveness analysis of strategies addressing gaps in acute ischemic stroke care.European stroke journal · 2026Article
- Machine learning models for CT-based classification of ischemic stroke onset time within or beyond 4.5 h: a comparison of approaches.European radiology · 2026Article
- Safety, Technical and Clinical Success of the Aperio Hybrid Thrombectomy Device in Acute Ischemic Stroke, a Prospective Post-market Clinical Follow-up Study (HYBRID).Clinical neuroradiology · 2026Article
- Treatment time metrics and functional outcomes after endovascular thrombectomy in routine clinical practice.Frontiers in neurology · 2026Article
- Microvascular Occlusion and Postrecanalization Hyperperfusion in a Swine Model of Acute Ischemic Stroke.Journal of the American Heart Association · 2025Article
- Outcomes After Thrombectomy for Acute Ischemic Stroke Related to Type of Stent Retriever; a MR CLEAN Registry Study.Cardiovascular and interventional radiology · 2025Article
- Semi-automated tortuosity measurements confirm generalizability of IMPERATIVE trial results to real-world patients with acute ischemic stroke undergoing thrombectomy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Trends in device utilization and procedural outcomes of endovascular treatment of acute ischemic stroke: A 10-year review of individual institutional experience.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Automatic prediction of stroke treatment outcomes: latest advances and perspectives.Biomedical engineering letters · 2025Review
- Predictive Modeling of Symptomatic Intracranial Hemorrhage Following Endovascular Thrombectomy: Insights From the Nationwide TREAT-AIS Registry.Journal of stroke · 2025Article
- Dynamic decline in estimated glomerular filtration rate associated with in-hospital mortality risk in acute ischemic stroke patients after endovascular therapy: evidence from a Chinese stroke center.Frontiers in aging neuroscience · 2025Article
- Optimal Endovascular Therapy Technique for Isolated Intracranial Atherothrombotic Stroke-Related Large-Vessel Occlusion in the Acute-to-Subacute Stage.AJNR. American journal of neuroradiology · 2024Article
- Characteristics, clinical profiles, and outcomes of patients undergoing endovascular thrombectomy: A retrospective study, Saudi Arabia.Journal of Taibah University Medical Sciences · 2024Article
- Perfusion Imaging-Based Triage for Acute Ischemic Stroke: Trends in Use and Impact on Clinical Outcomes.Stroke (Hoboken, N.J.) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
59 authors at 20 institutions in 5 countries.
Kars C J Compagne *Department of Radiology and Nuclear Medicine (K.C.J.C., P.J.v.D.), Erasmus MC, University Medical Center' Rotterdam' the Netherlands.ORCID 0000-0003-0608-835X
Manon Kappelhof *Department of Radiology and Nuclear Medicine (M.K., M.E.S.S., S.D.R., L.F.M.B., R.v.d.B., B.J.E., C.B.L.M.M.), Amsterdam UMC, University of Amsterdam' the Netherlands.ORCID 0000-0001-5250-8955
Wouter H HinsenveldDepartment of Neurology (W.H.H., R.-J.B.G., R.J.v.O.), School for Cardiovascular Diseases (CARIM), School for Mental Health and Sciences, Maastricht University Medical Center' the Netherlands.
Josje BrouwerDepartment of Neurology (J.B., J.M.C., Y.B.W.E.M.R.), Amsterdam UMC, University of Amsterdam' the Netherlands.ORCID 0000-0003-0301-2616
Robert-Jan B GoldhoornDepartment of Neurology (W.H.H., R.-J.B.G., R.J.v.O.), School for Cardiovascular Diseases (CARIM), School for Mental Health and Sciences, Maastricht University Medical Center' the Netherlands.ORCID 0000-0002-0062-2614
Maarten UyttenboogaartDepartment of Neurology (M.U.), University Medical Center Groningen' the Netherlands.ORCID 0000-0002-6934-4456
Reinoud P H BokkersDepartment of Radiology (R.P.H.B.), University Medical Center Groningen' the Netherlands.ORCID 0000-0001-6130-7311
Wouter J SchonewilleDepartment of Neurology (W.J.S.)' Sint Antonius Hospital' the Netherlands.
Jasper M MartensDepartment of Radiology (J.M.M.), Rijnstate Hospital' Arnhem' the Netherlands.ORCID 0000-0002-9418-4503
Jeannette HofmeijerDepartment of Neurology (J.H.), Rijnstate Hospital' Arnhem' the Netherlands.ORCID 0000-0002-7593-5674
H Bart van der WorpDepartment of Neurology and Neurosurgery, Brain Center (H.B.v.d.W.), University Medical Center Utrecht' the Netherlands.ORCID 0000-0001-9891-2136
Rob T H LoDepartment of Radiology (R.T.H.L.O.), University Medical Center Utrecht' the Netherlands.
Koos KeizerDepartment of Neurology (K.K.), Catharina Hospital' Eindhoven' the Netherlands.
Lonneke S F YoDepartment of Radiology (L.S.F.Y., M.G.M.K.), Catharina Hospital' Eindhoven' the Netherlands.
Geert J Lycklama À NijeholtDepartment of Radiology (G.J.L.à.N., E.G.), Haaglanden Medical Center' the Netherlands.
Heleen M den HertogDepartment of Neurology (H.M.d.H., P.S.F.), Isala Klinieken' the Netherlands.
Emiel J C SturmDepartment of Radiology (E.J.C.S., D.G.G.), Medical Spectrum Twente' the Netherlands.
Paul J A M BrouwersDepartment of Neurology (P.J.A.M.B.), Medical Spectrum Twente' the Netherlands.ORCID 0000-0001-6689-819X
Marianne A A van WalderveenDepartment of Radiology (M.A.A.v.W., A.C.G.M.v.E.), Leiden University Medical Center' the Netherlands.
Marieke J H WermerDepartment of Neurology (M.J.H.W.), Leiden University Medical Center' the Netherlands.ORCID 0000-0002-6838-9521
Sebastiaan F de BruijnDepartment of Neurology (S.F.d.B.), HAGA Hospital' the Netherlands.
Lukas C van DijkDepartment of Radiology (L.C.v.D.), HAGA Hospital' the Netherlands.ORCID 0000-0003-3156-1110
Hieronymus D BoogaartsDepartment of Neurosurgery (H.D.B.), Radboud University Medical Center' the Netherlands.
Ewout J van DijkDepartment of Neurology (E.J.v.D.), Radboud University Medical Center' the Netherlands.
Julia H van Tuijl
Jo P P PelusoDepartment of Radiology (J.P.P.), Sint Elisabeth Hospital' the Netherlands.ORCID 0000-0002-2027-0388
Paul L M de KortDepartment of Neurology (P.L.M.d.K.), Sint Elisabeth Hospital' the Netherlands.
Boudewijn A A M van HasseltDepartment of Radiology (B.A.A.M.v.H.), Isala Klinieken' the Netherlands.ORCID 0000-0002-3134-6210
Puck S FransenDepartment of Neurology (H.M.d.H., P.S.F.), Isala Klinieken' the Netherlands.
Tobien H C M L SchreuderDepartment of Neurology (T.H.C.M.L.), Zuyderland' the Netherlands.ORCID 0000-0003-1284-7922
Roel J J HeijboerDepartment of Radiology (R.J.J.H.), Zuyderland' the Netherlands.
Sjoerd F M JenniskensDepartment of Radiology (S.F.M.J., A.F.J.A.M.), Radboud University Medical Center' the Netherlands.
Marieke E S SprengersDepartment of Radiology and Nuclear Medicine (M.K., M.E.S.S., S.D.R., L.F.M.B., R.v.d.B., B.J.E., C.B.L.M.M.), Amsterdam UMC, University of Amsterdam' the Netherlands.ORCID 0000-0001-6895-1353
Elias GhariqDepartment of Radiology (G.J.L.à.N., E.G.), Haaglanden Medical Center' the Netherlands.
Ido R van den WijngaardDepartment of Neurology (I.R.v.d.W., J.B.), Haaglanden Medical Center' the Netherlands.ORCID 0000-0002-3734-6086
Stefan D RoosendaalDepartment of Radiology and Nuclear Medicine (M.K., M.E.S.S., S.D.R., L.F.M.B., R.v.d.B., B.J.E., C.B.L.M.M.), Amsterdam UMC, University of Amsterdam' the Netherlands.ORCID 0000-0002-3763-4774
Anton F J A MeijerDepartment of Radiology (S.F.M.J., A.F.J.A.M.), Radboud University Medical Center' the Netherlands.ORCID 0000-0001-5921-639X
Ludo F M BeenenDepartment of Radiology and Nuclear Medicine (M.K., M.E.S.S., S.D.R., L.F.M.B., R.v.d.B., B.J.E., C.B.L.M.M.), Amsterdam UMC, University of Amsterdam' the Netherlands.ORCID 0000-0001-9204-1026
Alida A PostmaDepartment of Radiology and Nuclear Medicine (A.A.P., W.H.v.Z.), School for Cardiovascular Diseases (CARIM), School for Mental Health and Sciences, Maastricht University Medical Center' the Netherlands.ORCID 0000-0002-1116-054X
René van den BergDepartment of Radiology and Nuclear Medicine (M.K., M.E.S.S., S.D.R., L.F.M.B., R.v.d.B., B.J.E., C.B.L.M.M.), Amsterdam UMC, University of Amsterdam' the Netherlands.ORCID 0000-0002-8791-8791
Albert J YooORCID 0000-0002-7657-142X
Pieter Jan van DoormaalDepartment of Radiology and Nuclear Medicine (K.C.J.C., P.J.v.D.), Erasmus MC, University Medical Center' Rotterdam' the Netherlands.ORCID 0000-0002-7398-2864
Marc P van ProosdijDepartment of Radiology, Noordwest Ziekenhuisgroep' the Netherlands (M.P.v.P.).
Menno G M KrietemeijerDepartment of Radiology (L.S.F.Y., M.G.M.K.), Catharina Hospital' Eindhoven' the Netherlands.
Dick G GerritsDepartment of Radiology (E.J.C.S., D.G.G.), Medical Spectrum Twente' the Netherlands.
Sebastiaan Hammer
Jan Albert VosDepartment of Radiology (J.A.V.)' Sint Antonius Hospital' the Netherlands.ORCID 0000-0003-3614-9168
Jelis BoitenDepartment of Neurology (I.R.v.d.W., J.B.), Haaglanden Medical Center' the Netherlands.
Jonathan M CoutinhoDepartment of Neurology (J.B., J.M.C., Y.B.W.E.M.R.), Amsterdam UMC, University of Amsterdam' the Netherlands.ORCID 0000-0002-8284-982X
Bart J EmmerDepartment of Radiology and Nuclear Medicine (M.K., M.E.S.S., S.D.R., L.F.M.B., R.v.d.B., B.J.E., C.B.L.M.M.), Amsterdam UMC, University of Amsterdam' the Netherlands.ORCID 0000-0003-1222-0652
Ad C G M van EsDepartment of Radiology (M.A.A.v.W., A.C.G.M.v.E.), Leiden University Medical Center' the Netherlands.ORCID 0000-0002-4820-5051
Bob RoozenbeekDepartment of Neurology (K.C.J.C., B.R., D.W.J.D.), Erasmus MC, University Medical Center' Rotterdam' the Netherlands.ORCID 0000-0002-8320-8303
Yvo B W E M RoosDepartment of Neurology (J.B., J.M.C., Y.B.W.E.M.R.), Amsterdam UMC, University of Amsterdam' the Netherlands.ORCID 0000-0001-9205-5882
Wim H van ZwamDepartment of Radiology and Nuclear Medicine (A.A.P., W.H.v.Z.), School for Cardiovascular Diseases (CARIM), School for Mental Health and Sciences, Maastricht University Medical Center' the Netherlands.ORCID 0000-0003-1631-7056
Robert J van OostenbruggeDepartment of Neurology (W.H.H., R.-J.B.G., R.J.v.O.), School for Cardiovascular Diseases (CARIM), School for Mental Health and Sciences, Maastricht University Medical Center' the Netherlands.ORCID 0000-0003-1032-9099
Charles B L M MajoieDepartment of Radiology and Nuclear Medicine (M.K., M.E.S.S., S.D.R., L.F.M.B., R.v.d.B., B.J.E., C.B.L.M.M.), Amsterdam UMC, University of Amsterdam' the Netherlands.ORCID 0000-0002-7600-9568
Diederik W J DippelDepartment of Neurology (K.C.J.C., B.R., D.W.J.D.), Erasmus MC, University Medical Center' Rotterdam' the Netherlands.ORCID 0000-0002-9234-3515
Aad van der LugtORCID 0000-0002-6159-2228
MR CLEAN Registry Investigators
Radboud University Nijmegen · NLMRC Holland (Netherlands) · NLMaastricht University · NLErasmus MC · NLRijnstate Hospital · NLKliniek ViaSana · NLLeiden University Medical Center · NLSt. Antonius Ziekenhuis · NLUniversity Medical Center Utrecht · NLGGD Haaglanden · NLMedisch Centrum Haaglanden · NLMedisch Spectrum Twente · NLHaga Hospital · NLSt. Elisabeth Hospital · CWUniversity Medical Center Groningen · NLUniversity of Amsterdam · NLUniversity of Jijel · DZVrije Universiteit Amsterdam · NLZuyderland Medisch Centrum · NLNoordwest Ziekenhuisgroep · NL
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe evaluated data from all patients in the Netherlands who underwent endovascular treatment for acute ischemic stroke in the past 3.5 years, to identify nationwide trends in time to treatment and procedural success, and assess their effect on clinical outcomes.
methodsWe included patients with proximal occlusions of the anterior circulation from the second and first cohorts of the MR CLEAN (Multicenter Randomized Clinical trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Registry (March 2014 to June 2016; June 2016 to November 2017, respectively). We compared workflow times and rates of successful reperfusion (defined as an extended Thrombolysis in Cerebral Infarction score of 2B-3) between cohorts and chronological quartiles (all included patients stratified in chronological quartiles of intervention dates to create equally sized groups over the study period). Multivariable ordinal logistic regression was used to assess differences in the primary outcome (ordinal modified Rankin Scale at 90 days).
resultsBaseline characteristics were similar between cohorts (second cohort n=1692, first cohort n=1488) except for higher age, poorer collaterals, and less signs of early ischemia on computed tomography in the second cohort. Time from stroke onset to groin puncture and reperfusion were shorter in the second cohort (median 185 versus 210 minutes;
conclusionsClinical outcomes after endovascular treatment for acute ischemic stroke in routine clinical practice have improved over the past years, likely resulting from improved workflow times and higher successful reperfusion rates.
Indexed as
Brain IschemiaEndovascular ProceduresIschemic StrokeStrokeHumansLongitudinal StudiesRegistriesThrombectomyTreatment Outcomegroin oddspunctureratioregistryreperfusion
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