ArticleEuropean heart journal2022
Sex-related differences in treatment and outcome of chronic limb-threatening ischaemia: a real-world cohort.
Article in European heart journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Initial side effects of roxadustat on thyroid function in patients undergoing hemodialysis.Renal failure · 2026Article
- Sex-specific differences in disease severity and outcomes in left ventricular heart failure: a nationwide cohort study.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Parity in Patency? Efficacy of Resorbable Scaffold by Sex in LIFE-BTK.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- Factors associated with all-cause mortality in endovascularly treated patients with chronic limb-threatening ischemia.Frontiers in epidemiology · 2026Article
- Limited Prognostic Value of Psoas Muscle Indices in Patients Undergoing Revascularization for Chronic Limb-Threatening Ischemia.Medical sciences (Basel, Switzerland) · 2025Article
- Unveiling the Sex-Based Divide: Exploring Sex Differences in Peripheral Artery Disease.Current atherosclerosis reports · 2025Review
- Engaging patients and their caregivers in research to improve evidence-based, patient-centered and equitable care for chronic limb-threatening ischemia and advanced peripheral artery disease.JVS-vascular insights · 2025Article
- Evaluation of sex-based differences in below-the-knee plaque histology in patients who underwent amputation for chronic limb-threatening ischemia.JVS-vascular science · 2025Article
- Wound formation in patients with Rutherford category IV disease after endovascular therapy: rates and risk factors.CVIR endovascular · 2024Article
- BMI-Stratified Exploration of the 'Obesity Paradox': Heart Failure Perspectives from a Large German Insurance Database.Journal of clinical medicine · 2024Article
- Antithrombotic therapy following revascularization for chronic limb-threatening ischaemia: a European survey from the ESC Working Group on Aorta and Peripheral Vascular Diseases.European heart journal. Cardiovascular pharmacotherapy · 2023Article
- Sex-Related Differences and Factors Associated with Peri-Procedural and 1 Year Mortality in Chronic Limb-Threatening Ischemia Patients from the CLIMATE Italian Registry.Journal of personalized medicine · 2023Article
- Use of big data from health insurance for assessment of cardiovascular outcomes.Frontiers in artificial intelligence · 2023Review
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe prevalence of chronic limb-threatening ischaemia (CLTI) is increasing and available data often derive from cohorts with various selection criteria. In the present study, we included CLTI patients and studied sex-related differences in their risk profile, vascular procedures, and long-term outcome. METHODS AND
resultsWe analysed 199 953 unselected patients of the largest public health insurance in Germany (AOK: Local healthcare funds), hospitalized between 2010 and 2017 for a main diagnosis of CLTI. A baseline period of 2 years before index hospitalization to assess comorbidities and previous procedures, and a follow-up period until 2018 were included. Female CLTI patients were older (median 81.4 vs. 73.8 years in males; P < 0.001) and more often diagnosed with hypertension, atrial fibrillation, chronic heart failure, and chronic kidney disease. Male patients suffered more frequently from diabetes mellitus, dyslipidaemia, smoking, cerebrovascular disease, and chronic coronary syndrome (all P < 0.001). Within hospitalized CLTI patients, females represent the minority (43% vs. 57%; P < 0.001) and during index hospitalization, women underwent less frequently diagnostic angiographies (67 vs. 70%) and revascularization procedures (61 vs. 65%; both P < 0.001). Moreover, women received less frequently guideline-recommended drugs like statins (35 vs. 43%) and antithrombotic therapy (48 vs. 53%; both P < 0.001) at baseline. Interestingly, after including age and comorbidities in a Cox regression analysis, female sex was associated with increased overall-survival (OS) [hazard ratio (HR) 0.95; 95% confidence interval (CI) 0.94-0.96] and amputation-free survival (AFS) (HR 0.84; 95% CI 0.83-0.85; both P < 0.001).
conclusionFemale patients with CLTI were older, underwent less often vascular procedures, and received less frequently guideline-recommended medication. Nevertheless, female sex was independently associated with better OS and AFS during follow-up.
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