Evidence map›Paper›PMID 35134811›Full record

ReviewActa haematologica2022

COVID-19 in Patients with Hematologic Malignancies: Outcomes and Options for Treatments.

José Carlos Martínez, R Alejandro Sica, Keith Stockerl-Goldstein, Samuel M Rubinstein

Open access · bronzeAbstract readReview
In one paragraph

Review in Acta haematologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Association of Cancer History with COVID-19 Risk and Outcomes among Older Postmenopausal Women: Results from the Women's Health Initiative.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

José Carlos MartínezDivision of Hematology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
R Alejandro SicaAlbert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA.
Keith Stockerl-GoldsteinDivision of Oncology, Washington University School of Medicine, St. Louis, Michigan, USA.
Samuel M RubinsteinDivision of Hematology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
University of North Carolina at Chapel Hill · USAlbert Einstein College of Medicine · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with hematologic malignancies are particularly vulnerable to infections due to underlying humoral and cellular immune dysfunction, cytotoxic chemotherapy regimens, advanced age, and the presence of comorbid conditions. Infection from severe acute respiratory syndrome coronavirus 2, the causative agent of the COVID-19 pandemic, has become a leading cause of death globally and has disproportionally affected this high-risk population. Here, we review the cumulative evidence demonstrating worse outcomes for patients with hematologic malignancies when compared to patients with solid tumors and the general population. We examine risk factors shared with the general population (age, sex, comorbid conditions, and race) and those that are cancer-specific (cytotoxic chemotherapy, progressive disease, and cancer type), all of which confer an increased risk of severe COVID-19. Despite the historical exclusion of cancer patients from COVID-19 therapy trials, we review the emerging evidence that patients with hematologic malignancies benefit from specific treatments such as convalescent plasma. Although COVID-19 vaccines are significantly less effective in this patient population, encouraging results are observed in a subset of these patients after receiving a booster dose.

Indexed as

COVID-19Hematologic NeoplasmsNeoplasmsCOVID-19 SerotherapyCOVID-19 VaccinesHumansImmunization, PassivePandemicsCOVID-19 VaccinesCoronavirus disease 19Hematologic malignanciesOutcomes

Identifiers

PMID35134811
PMCPMC9059013
OpenAlexW4210938784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.