Evidence map›Paper›PMID 35134736›Full record

Observational studyJournal de mycologie medicale2022

Pathogenetic factors fanning the flames of COVID-19 to cause rhino-orbito-cerebral mucormycosis: An observational study.

Y Muralidhar Reddy, Sreekanth Yeduguri, Vishnu Swaroop Reddy N, Subhendu Parida, Shanti Naidu Kamatham, Lalitha Pidaparthi, Shyam K Jaiswal, Bhavana Sadhvani, Vijaya Tourani, Sudhir Kumar and 2 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal de mycologie medicale, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Correlation of Interleukin-6 Levels With Disease Severity in Rhino-Orbito-Cerebral Mucormycosis: A Prospective Study.Journal of rhinology : official journal of the Korean Rhinologic Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Y Muralidhar ReddyDepartment of Neurology, CARE Hospital, Banjara Hills, Hyderabad, India. Electronic address: muralidharnims@gmail.com.
Sreekanth YeduguriDepartment of Neurology, CARE Hospital, Banjara Hills, Hyderabad, India.
Vishnu Swaroop Reddy NDepartment of E.N.T, CARE Hospital, Banjara Hills, Hyderabad, India.
Subhendu ParidaDepartment of Neurology, CARE Hospital, Banjara Hills, Hyderabad, India.
Shanti Naidu KamathamDepartment of Biochemistry, CARE Hospital, Banjara Hills, Hyderabad, India.
Lalitha PidaparthiDepartment of Neurology, CARE Hospital, Banjara Hills, Hyderabad, India.
Shyam K JaiswalDepartment of Neurology, CARE Hospital, Banjara Hills, Hyderabad, India.
Bhavana SadhvaniDepartment of Pathology, CARE Hospital, Banjara Hills, Hyderabad, India.
Vijaya TouraniDepartment of Pathology, CARE Hospital, Banjara Hills, Hyderabad, India.
Sudhir KumarDepartment of Biostatistics, CARE Hospital, Banjara Hills, Hyderabad, India.
Sundaram ChallaDepartment of Pathology, Basavatarakam Indo American Cancer Hospital & Research Institute, Hyderabad, India.
Jagarlapudi Mk MurthyDepartment of Neurology, CARE Hospital, Banjara Hills, Hyderabad, India.
CARE Hospitals · INBasavatarakam Indo American Cancer Hospital and Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsPublished studies on coronavirus disease 19 (COVID-19) associated rhino-orbito-cerebral mucormycosis (CAROCM) were primarily descriptive. Therefore, we aimed to identify features of COVID-19 that could predispose to CAROCM and explore the pathogenic pathways. PATIENTS AND

methodsThis retrospective hospital-based study was done during the first (March 2020 - January 2021) and the second (February 2021 - June 2021) waves of the COVID-19 pandemic. Subjects were grouped into four categories: first-wave CAROCM (n-4); second-wave CAROCM (n-27); first-wave non-mucor COVID (n-75), and second-wave non-mucor COVID (n-50). Data elements included age, gender, comorbidities, COVID-19 severity, steroid therapy, peak values of interleukin-6 (IL-6), serum ferritin and D-dimer, nadir values of absolute lymphocyte count (ALC), absolute neutrophil count (ANC) and platelet count (Pl. C).

resultsThirty-one patients of CAROCM were included. The mean (SD) age was 51.26 (11.48) years. 27 (87.1%) were aged ≥ 40 years and males. Severe COVID-19 was seen more often in the second wave than the first wave (P-0.001). CAROCM group was significantly younger (P-0.008) and showed a higher incidence of uncontrolled diabetes (P-0.001) and renal dysfunction (P-0.004) than non-mucor COVID. While IL-6, ferritin and D-dimer were significantly elevated in CAROCM than non-mucor COVID, clinical severity, ANC, ALC and Pl. C showed no significant difference.

conclusionCAROCM is seen often in middle-aged diabetic males with uncontrolled hyperglycaemia, diabetic ketoacidosis, renal dysfunction and those infected by more transmissible delta variants and treated with steroids. IL-6, D-dimer, serum ferritin are more often elevated in CAROCM and might play a pathogenic role.

Indexed as

COVID-19Diabetic KetoacidosisKidney DiseasesMucormycosisFerritinsHumansInterleukin-6MaleMiddle AgedPandemicsRetrospective StudiesSARS-CoV-2Virulence FactorsFerritinsInterleukin-6Virulence FactorsCoronavirus disease-19Cytokine stormDelta variantsDiabetesHyperferritinemiaRhino-orbito-cerebral mucormycosis

Identifiers

PMID35134736
PMCPMC8806396
OpenAlexW4210253554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.