Evidence map›Paper›PMID 35134705›Full record

ArticleNeuroImage. Clinical2022

Concordance of regional hypoperfusion by pCASL MRI and

Tracy Ssali, Lucas Narciso, Justin Hicks, Linshan Liu, Sarah Jesso, Lauryn Richardson, Matthias Günther, Simon Konstandin, Klaus Eickel, Frank Prato and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Simultaneous multiple post-labelling delay ASL MRI and [European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Tracy SsaliLawson Health Research Institute, London, Canada; Department of Medical Biophysics, Western University, London, Canada. Electronic address: tssali@uwo.ca.
Lucas NarcisoLawson Health Research Institute, London, Canada; Department of Medical Biophysics, Western University, London, Canada.
Justin HicksLawson Health Research Institute, London, Canada; Department of Medical Biophysics, Western University, London, Canada.
Linshan LiuLawson Health Research Institute, London, Canada; Department of Medical Biophysics, Western University, London, Canada.
Sarah JessoLawson Health Research Institute, London, Canada; St. Joseph's Health Care, London, Canada.
Lauryn RichardsonLawson Health Research Institute, London, Canada; St. Joseph's Health Care, London, Canada.
Matthias GüntherFraunhofer Institute for Medical Image Computing MEVIS, Bremen, Germany; University Bremen, Bremen, Germany.
Simon KonstandinFraunhofer Institute for Medical Image Computing MEVIS, Bremen, Germany; Mediri GmbH, Heidelberg, Germany.
Klaus EickelMediri GmbH, Heidelberg, Germany.
Frank PratoLawson Health Research Institute, London, Canada; Department of Medical Biophysics, Western University, London, Canada.
Udunna C AnazodoLawson Health Research Institute, London, Canada; Department of Medical Biophysics, Western University, London, Canada.
Elizabeth FingerLawson Health Research Institute, London, Canada; Department of Medical Biophysics, Western University, London, Canada; Department of Clinical Neurological Sciences, Western University, London, Canada.
Keith St LawrenceLawson Health Research Institute, London, Canada; Department of Medical Biophysics, Western University, London, Canada.
Western University · CALawson Health Research Institute · CAMediri (Germany) · DEUniversity of Bremen · DE

Funding

CIHR
6 · The paper itself

Abstract

backgroundClinical diagnosis of frontotemporal dementia (FTD) remains a challenge due to the overlap of symptoms among FTD subtypes and with other psychiatric disorders. Perfusion imaging by arterial spin labeling (ASL) is a promising non-invasive alternative to established PET techniques; however, its sensitivity to imaging parameters can hinder its ability to detect perfusion abnormalities. PURPOSE: This study evaluated the similarity of regional hypoperfusion patterns detected by ASL relative to the gold standard for imaging perfusion, PET with radiolabeled water ( METHODS AND MATERIALS: Perfusion by single-delay pseudo continuous ASL (SD-pCASL), free-lunch Hadamard encoded pCASL (FL_TE-pCASL), and

resultsRegion of interest (ROI) based perfusion measured by

conclusionsThis study demonstrates the potential of pCASL for assessing regional hypoperfusion related to FTD and supports its use as a cost-effective alternative to PET.

Indexed as

Frontotemporal DementiaCerebrovascular CirculationHumansMagnetic Resonance ImagingSpin LabelsTomography, X-Ray ComputedWaterSpin LabelsWaterArterial spin labeling (ASL)Cerebral blood flow (CBF)Frontotemporal dementia (FTD)PET/MRIRadiolabeled water PET ((15)O-water)sensitivity

Identifiers

PMID35134705
PMCPMC8829802
OpenAlexW4210458730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.