ArticleNeuroImage. Clinical2022
Ventricular features as reliable differentiators between bvFTD and other dementias.
Article in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- A Case of Early-Onset VCP-Related Frontotemporal Dementia: Insights from Neuroimaging and Genetic Analysis.The Yale journal of biology and medicine · 2026Article
- Altered cerebrospinal fluid-based clearance mechanisms in aging autistic adults.Research square · 2026Article
- Quantifying brain atrophy in Frontotemporal Dementia: a head-to-head comparison of neuroimaging techniques.medRxiv : the preprint server for health sciences · 2025Article
- Frontotemporal dementia subtyping using machine learning, multivariate statistics and neuroimaging.Brain communications · 2025Article
- Integration of Neuroimaging and Molecular Biomarkers in the Diagnosis of Alzheimer's Disease and Frontotemporal Dementia: The Promise of fMRI.Current Alzheimer research · 2025Review
- Microstructural grey matter alterations in patients with behavioural variant frontotemporal dementia.Brain communications · 2025Article
- VentRa: distinguishing frontotemporal dementia from psychiatric disorders.Brain communications · 2024Article
- Sex differences in risk factors, burden, and outcomes of cerebrovascular disease in Alzheimer's disease populations.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The Anatomic Variability of the Lateral Ventricles of the Human Brain Depending on Age and Sex.Cureus · 2023Article
- Topographical differences in white matter hyperintensity burden and cognition in aging, MCI, and AD.GeroScience · 2023Article
- Tissue volume estimation and age prediction using rapid structural brain scans.Scientific reports · 2022Article
- A Reproducible Deep-Learning-Based Computer-Aided Diagnosis Tool for Frontotemporal Dementia Using MONAI and Clinica Frameworks.Life (Basel, Switzerland) · 2022Article
- MNI-FTD templates, unbiased average templates of frontotemporal dementia variants.Scientific data · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
introductionLateral ventricles are reliable and sensitive indicators of brain atrophy and disease progression in behavioral variant frontotemporal dementia (bvFTD). We aimed to investigate whether an automated tool using ventricular features could improve diagnostic accuracy in bvFTD across neurodegenerative diseases.
methodsUsing 678 subjects -69 bvFTD, 38 semantic variant, 37 primary non-fluent aphasia, 218 amyloid + mild cognitive impairment, 74 amyloid + Alzheimer's Dementia and 242 normal controls- with a total of 2750 timepoints, lateral ventricles were segmented and differences in ventricular features were assessed between bvFTD, normal controls and other dementia cohorts.
resultsVentricular antero-posterior ratio (APR) was the only feature that was significantly different and increased faster in bvFTD compared to all other cohorts. We achieved a 10-fold cross-validation accuracy of 80% (77% sensitivity, 82% specificity) in differentiating bvFTD from all other cohorts with other ventricular features (i.e., total ventricular volume and left-right lateral ventricle ratios), and 76% accuracy using only the single APR feature. DISCUSSION: Ventricular features, particularly the APR, might be reliable and easy-to-implement markers for bvFTD diagnosis. We have made our ventricle feature estimation and bvFTD diagnostic tool publicly available, allowing application of our model in other studies.
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