Evidence map›Paper›PMID 35134654›Full record

ArticleAtherosclerosis2022

Histopathological correlation of near infrared autofluorescence in human cadaver coronary arteries.

Mie Kunio, Joseph A Gardecki, Kohei Watanabe, Kensuke Nishimiya, Sarika Verma, Farouc A Jaffer, Guillermo J Tearney

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  4. Ultrathin-strut versus thin-strut stent healing and outcomes in preclinical and clinical subjects.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mie KunioCanon U.S.A., Inc., Cambridge, MA, USA; Wellman Center of Photomedicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: mie.kunio@yahoo.com.
Joseph A GardeckiWellman Center of Photomedicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Kohei WatanabeCanon U.S.A., Inc., Cambridge, MA, USA; Wellman Center of Photomedicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Kensuke NishimiyaWellman Center of Photomedicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Sarika VermaCanon U.S.A., Inc., Cambridge, MA, USA.
Farouc A JafferWellman Center of Photomedicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Cardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Guillermo J TearneyWellman Center of Photomedicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: gtearney@partners.org.
Harvard University · USCanon (United States) · US

Funding

Novel PET/CT and Treatment Strategies to reduce PTS following DVTR01HL137913 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JAFFER, FAROUC AMIN, TAWAKOL, AHMED A · 2017 to 2020
$3.3M
Intravascular NIRF-IVUS imaging of inflammation-guided arterial therapyR01HL150538 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JAFFER, FAROUC AMIN · 2020 to 2023
$2.2M
NHLBI NIH HHS R01 HL137913NHLBI NIH HHS R01 HL150538
6 · The paper itself

Abstract

BACKGROUND AND

aimsPrior coronary optical coherence tomography (OCT)-near infrared auto-fluorescence (NIRAF) imaging data has shown a correlation between high-risk morphological features and NIRAF signal intensity. This study aims to understand the histopathological origins of NIRAF in human cadaver coronary arteries.

methodsEx vivo intracoronary OCT-NIRAF imaging was performed on coronary arteries prosected from 23 fresh human cadaver hearts. Arteries with elevated NIRAF were formalin-fixed and paraffin-embedded. Microscopic images of immunostained Glycophorin A (indicating intraplaque hemorrhage) and Sudan Black (indicating ceroid after fixation) stained slides were compared with confocal NIRAF images (ex. 635 nm, em. 655-755 nm) from adjacent unstained slides in each section. Different images from the same section were registered via luminal morphology. Confocal NIRAF-positive 45° sectors were compared to immunohistochemistry and colocalization between NIRAF and intraplaque hemorrhage or ceroid was quantified by Manders' overlap and Dice similarity coefficients.

resultsThirty-one coronary arteries from 14 hearts demonstrated ≥1.5 times higher NIRAF signal than background, and 429 sections were created from them, including 54 sections (12.6%) with high-risk plaques. Within 112 confocal NIRAF-positive 45° sectors, 65 sectors (58.0%) showed both Glycophorin A-positive and Sudan Black-positive, while 7 sectors (6.3%) and 40 sectors (33.6%) only showed Glycophorin A-positive or Sudan black-positive, respectively. A two-tailed McNemar's test showed that Sudan Black more closely corresponded to confocal NIRAF than Glycophorin A (p < 1.0 × 10

conclusionsAs ceroid associates with oxidative stress and intraplaque hemorrhage is implicated in rapid lesion progression, these results suggest that NIRAF provides additional, complementary information to morphologic imaging that may aid in identifying high-risk coronary plaques via translatable intracoronary OCT-NIRAF imaging.

Indexed as

Coronary Artery DiseasePlaque, AtheroscleroticCadaverCoronary VesselsHemorrhageHumansTomography, Optical CoherenceAtherosclerosisCeroidIntraplaque hemorrhageNear-infrared auto-fluorescenceOxidized lipoproteinPlaque destabilizationPlaque progression

Identifiers

PMID35134654
PMCPMC9106423
OpenAlexW4210440134

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.