Evidence map›Paper›PMID 35134598›Full record

ArticleThe International journal on drug policy2022

Stigma and ART initiation among people with HIV and a lifetime history of illicit drug use in Saint-Petersburg, Russia-A prospective cohort analysis.

Marina Vetrova, Sara Lodi, Lindsey Rateau, Gregory Patts, Elena Blokhina, Vladimir Palatkin, Tatiana Yaroslavtseva, Olga Toussova, Natalia Bushara, Sally Bendiks and 5 more

Open access · hybridAbstract read
In one paragraph

Article in The International journal on drug policy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Interventions to reduce self-stigma in people who use drugs: A systematic review.Journal of substance use and addiction treatment · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Provider-patient experiences and HIV care utilization among people living with HIV who inject drugs in St. Petersburg, Russia.International journal for quality in health care : journal of the International Society for Quality in Health Care · 2023
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Marina VetrovaFirst Pavlov State Medical University of Saint Petersburg, 6-8 Lev Tolstoy Street, St. Petersburg, 197022, Russia. Electronic address: mvetrova111@gmail.com.
Sara LodiBoston University School of Public Health, 715 Albany Street, Boston, MA, 02118, USA.
Lindsey RateauBoston University School of Public Health, 715 Albany Street, Boston, MA, 02118, USA.
Gregory PattsBoston University School of Public Health, 715 Albany Street, Boston, MA, 02118, USA.
Elena BlokhinaFirst Pavlov State Medical University of Saint Petersburg, 6-8 Lev Tolstoy Street, St. Petersburg, 197022, Russia.
Vladimir PalatkinFirst Pavlov State Medical University of Saint Petersburg, 6-8 Lev Tolstoy Street, St. Petersburg, 197022, Russia.
Tatiana YaroslavtsevaFirst Pavlov State Medical University of Saint Petersburg, 6-8 Lev Tolstoy Street, St. Petersburg, 197022, Russia.
Olga ToussovaFirst Pavlov State Medical University of Saint Petersburg, 6-8 Lev Tolstoy Street, St. Petersburg, 197022, Russia.
Natalia BusharaFirst Pavlov State Medical University of Saint Petersburg, 6-8 Lev Tolstoy Street, St. Petersburg, 197022, Russia.
Sally BendiksBoston Medical Center, 801 Massachusetts Ave Crosstown, Boston, MA, USA.
Natalia GnatienkoBoston Medical Center, 801 Massachusetts Ave Crosstown, Boston, MA, USA.
Evgeny KrupitskyFirst Pavlov State Medical University of Saint Petersburg, 6-8 Lev Tolstoy Street, St. Petersburg, 197022, Russia; Bekhterev National Medical Research Center of Psychiatry and Neurology, 3 Bekhterev Street, Saint Petersburg, 192019, Russia.
Dmitry LioznovFirst Pavlov State Medical University of Saint Petersburg, 6-8 Lev Tolstoy Street, St. Petersburg, 197022, Russia; Smorodintsev Research Institute of Influenza, Prof. Popov Street, 15/17, Saint Petersburg, 197376, Russia.
Jeffrey H SametBoston University School of Public Health, 715 Albany Street, Boston, MA, 02118, USA; Boston Medical Center, 801 Massachusetts Ave Crosstown, Boston, MA, USA; Boston University School of Medicine, 72 E Concord Street, Boston, MA, 02118,USA.
Karsten LunzeBoston University School of Public Health, 715 Albany Street, Boston, MA, 02118, USA; Boston University School of Medicine, 72 E Concord Street, Boston, MA, 02118,USA.
First Pavlov State Medical University of St. Petersburg · RUBoston University · USBoston Medical Center · USResearch Institute of Influenza · RU

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH, DEBBIE M. CHENG · 1998 to 2026
$51.7M
URBAN ARCH 4/5 Russia Cohort-Targeting HIV-comorbidities with Pharmacotherapy to Reduce Alcohol and Tobacco Use in HIV-infected RussiansU01AA020780 · NIAAA · BOSTON MEDICAL CENTER · PI FREIBERG, MATTHEW S, SAMET, JEFFREY H. · 2011 to 2021
$4.4M
URBAN ARCH (2/5) Biostatistics and Data Management Core (BDM)U24AA020779 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHENG, DEBBIE M. · 2011 to 2020
$3.6M
URBAN ARCH (1/5) Administrative Coordinating Core (Admin Core)U24AA020778 · NIAAA · BOSTON MEDICAL CENTER · PI SAMET, JEFFREY H. · 2011 to 2020
$3.5M
Zinc for HIV Disease among Alcohol Users -An RCT in the Russia ARCH CohortU01AA021989 · NIAAA · BOSTON MEDICAL CENTER · PI FREIBERG, MATTHEW S, SAMET, JEFFREY H. · 2012 to 2016
$3.3M
Stigma, Risk Behaviors and Health Care among HIV-infected Russian People Who Inject DrugsR00DA041245 · NIDA · BOSTON MEDICAL CENTER · PI LUNZE, KARSTEN · 2018 to 2020
$906k
Stigma, Risk Behaviors and Health Care among HIV-infected Russian People Who Inject DrugsK99DA041245 · NIDA · BOSTON MEDICAL CENTER · PI LUNZE, KARSTEN · 2016 to 2017
$355k
NIAAA NIH HHS U01 AA020780NIAAA NIH HHS U01 AA021989NIAAA NIH HHS U24 AA020778NIAAA NIH HHS U24 AA020779NIAID NIH HHS P30 AI042853NIDA NIH HHS K99 DA041245NIDA NIH HHS R00 DA041245
6 · The paper itself

Abstract

backgroundHIV-positive people who inject drugs (PWID) are stigmatized and face more challenges in accessing ART. The natural course of stigma and its role on ART initiation in this population is unclear. We examined 1] whether HIV stigma changes over time and 2] whether HIV and substance use stigma are associated with ART initiation in a prospective cohort of HIV-positive PWID in St. Petersburg, Russia.

methodsWe used data from 165 HIV-positive PWID who were ART-naïve at enrollment andgeneralized estimating equations to assess changes in HIV stigma between baseline, 12- and 24-month study visits. Logistic regression estimated associations of HIV stigma and substance use stigma with ART initiation. All models were adjusted for gender, age, CD4 count, duration of HIV diagnosis, recent (past 30-day) drug use and depressive symptoms.

resultsParticipants characteristics were the following: median age of 34 (Q1; Q3: 30; 37) years; 30% female; 28% with CD4 count <350; 44% reported recent drug use. During the study period, 31% initiated ART and the median time between HIV diagnosis and ART initiation was 8.5 years (Q1; Q3: 4.68; 13.61). HIV stigma scores decreased yearly by 0.57 (95% CI -1.36, 0.22). More than half (27/47 [57.4%]) of participants who were eligible for ART initiation per local ART guidelines did not initiate therapy. Total HIV stigma and substance use stigma scores were not associated with ART initiation (AOR 0.99, 95%CI 0.94-1.04; AOR 1.01, 95%CI 0.96-1.05, respectively).

conclusionIn this Russian cohort of HIV-positive, ART-naïve PWID, stigma did not change over time and was not associated with ART initiation. Addressing stigma alone is unlikely to increase ART initiation rates in this population. Reducing further existing structural barriers, e.g., by promoting equal access to ART and the value of substance-use treatment for ART treatment success should complement stigma-reduction approaches.

Indexed as

HIV InfectionsIllicit DrugsSubstance Abuse, IntravenousSubstance-Related DisordersAdultCohort StudiesFemaleHumansMaleProspective StudiesIllicit DrugsAntiretroviral therapyLinkage to carePeople who inject drugsRussiaStigmaSubstance use disorders

Identifiers

PMID35134598
PMCPMC8960362
OpenAlexW4210796515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.