ArticleCurrent biology : CB2022
Striatal dopamine signals are region specific and temporally stable across action-sequence habit formation.
Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Sequence termination cues drive automated habit-like strategy via dopamine-mediated processes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Striatal dopamine signals internal states related to behavioral performance over prolonged timescales in monkeys.bioRxiv : the preprint server for biology · 2026Article
- Intermittency and Predictability of a Cafeteria Diet Shape Food Intake, Adiposity, and Neurobehavioral Outcomes in Rats.Nutrients · 2026Article
- Basolateral amygdala dopamine transmits emotional salience.Nature communications · 2026Article
- Spatiotemporally Distinct Dopamine Domains in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Revealing abrupt transitions from goal-directed to habitual behavior.Nature communications · 2026Article
- Neurodegenerative Disease Movement Disorders and Dorsal Striatum-Mediated Imbalance of Habitual Motor Sequences.Molecular neurobiology · 2025Review
- Sequence termination cues drive habits via dopamine-mediated credit assignment.bioRxiv : the preprint server for biology · 2025Article
- Striatal astrocytes modulate behavioral flexibility and whole-body metabolism in mice.Nature communications · 2025Article
- A Comparative Study of Short-Term Social Media Use with Face-to-Face Interaction in Adolescence.Children (Basel, Switzerland) · 2025Article
- Pallidal prototypic neuron and astrocyte activities regulate flexible reward-seeking behaviors.bioRxiv : the preprint server for biology · 2025Article
- Striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits.Current biology : CB · 2024Article
- Pre-existing visual responses in a projection-defined dopamine population explain individual learning trajectories.Current biology : CB · 2024Article
- Article
- Striosomes Target Nigral Dopamine-Containing Neurons via Direct-D1 and Indirect-D2 Pathways Paralleling Classic Direct-Indirect Basal Ganglia Systems.bioRxiv : the preprint server for biology · 2024Article
- Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning.Current biology : CB · 2024Article
- Article
- Value-Driven Adaptations of Mesolimbic Dopamine Release Are Governed by Both Model-Based and Model-Free Mechanisms.eNeuro · 2024Article
- Article
- Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning.bioRxiv : the preprint server for biology · 2024Article
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10 authors.
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Abstract
Habits are automatic, inflexible behaviors that develop slowly with repeated performance. Striatal dopamine signaling instantiates this habit-formation process, presumably region specifically and via ventral-to-dorsal and medial-to-lateral signal shifts. Here, we quantify dopamine release in regions implicated in these presumed shifts (ventromedial striatum [VMS], dorsomedial striatum [DMS], and dorsolateral striatum [DLS]) in rats performing an action-sequence task and characterize habit development throughout a 10-week training. Surprisingly, all regions exhibited stable dopamine dynamics throughout habit development. VMS and DLS signals did not differ between habitual and non-habitual animals, but DMS dopamine release increased during action-sequence initiation and decreased during action-sequence completion in habitual rats, whereas non-habitual rats showed opposite effects. Consistently, optogenetic stimulation of DMS dopamine release accelerated habit formation. Thus, we demonstrate that dopamine signals do not shift regionally during habit formation and that dopamine in DMS, but not VMS or DLS, determines habit bias, attributing "habit functions" to a region previously associated exclusively with non-habitual behavior.
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