ArticleThe Journal of comparative neurology2022
Molecular ontology of the parabrachial nucleus.
Article in The Journal of comparative neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 48 citations in OpenAlex.
- Molecular Ontology Predicts Output Connections From the Nucleus of the Solitary Tract.The Journal of comparative neurology · 2026Article
- ParabrachialProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Intersectional expression ofAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Fine mapping of PTSD GWAS reveals a role for amygdalabioRxiv : the preprint server for biology · 2026Article
- Conserved sleep disturbances in FOXP1 syndrome originate from developmental dysregulation of peptidergic signaling.The Journal of clinical investigation · 2026Article
- Nps-Expressing Neurons Receive Extensive Input From Auditory Brainstem Nuclei.The Journal of comparative neurology · 2026Article
- AAV-PHP.eB Peripheral Delivery and Central Expression in Cre Mice.The Journal of comparative neurology · 2026Article
- A bottom-up septal inhibitory circuit mediates anticipatory control of drinking.Nature neuroscience · 2025Article
- Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Article
- NPS neurons receive extensive input from auditory brainstem nuclei.bioRxiv : the preprint server for biology · 2025Article
- ParabrachialiScience · 2025Article
- Serotonin neurons are necessary for tonic sodium intake inhibition.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Neuroanatomical and neurochemical organization of brainstem and forebrain circuits involved in breathing regulation.Journal of neurophysiology · 2025Review
- Afferent Projections to the Calca/CGRP-Expressing Parabrachial Neurons in Mice.The Journal of comparative neurology · 2025Article
- Computational Approaches for Uncovering Interoceptive Mechanisms in Psychiatric Disorders and Their Biological Basis.Current topics in behavioral neurosciences · 2025Review
- Molecular Ontology of the Nucleus of Solitary Tract.The Journal of comparative neurology · 2024Article
- Sodium Leak Channel in Glutamatergic Neurons of the Lateral Parabrachial Nucleus Helps to Maintain Respiratory Frequency Under Sevoflurane Anesthesia.Neuroscience bulletin · 2024Article
- Vertebrate behavioral thermoregulation: knowledge and future directions.Neurophotonics · 2024Review
- Efferent projections of Nps-expressing neurons in the parabrachial region.The Journal of comparative neurology · 2024Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Diverse neurons in the parabrachial nucleus (PB) communicate with widespread brain regions. Despite evidence linking them to a variety of homeostatic functions, it remains difficult to determine which PB neurons influence which functions because their subpopulations intermingle extensively. An improved framework for identifying these intermingled subpopulations would help advance our understanding of neural circuit functions linked to this region. Here, we present the foundation of a developmental-genetic ontology that classifies PB neurons based on their intrinsic, molecular features. By combining transcription factor labeling with Cre fate-mapping, we find that the PB is a blend of two, developmentally distinct macropopulations of glutamatergic neurons. Neurons in the first macropopulation express Lmx1b (and, to a lesser extent, Lmx1a) and are mutually exclusive with those in a second macropopulation, which derive from precursors expressing Atoh1. This second, Atoh1-derived macropopulation includes many Foxp2-expressing neurons, but Foxp2 also identifies a subset of Lmx1b-expressing neurons in the Kölliker-Fuse nucleus (KF) and a population of GABAergic neurons ventrolateral to the PB ("caudal KF"). Immediately ventral to the PB, Phox2b-expressing glutamatergic neurons (some coexpressing Lmx1b) occupy the KF, supratrigeminal nucleus, and reticular formation. We show that this molecular framework organizes subsidiary patterns of adult gene expression (including Satb2, Calca, Grp, and Pdyn) and predicts output projections to the amygdala (Lmx1b), hypothalamus (Atoh1), and hindbrain (Phox2b/Lmx1b). Using this molecular ontology to organize, interpret, and communicate PB-related information could accelerate the translation of experimental findings from animal models to human patients.
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