ArticleDiagnostic cytopathology2022
Criteria for follow-up of thyroid nodules diagnosed as follicular neoplasm without molecular testing - The experience of a high-volume thyroid centre in Japan.
Article in Diagnostic cytopathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Impact of Molecular Testing on Surgical Decision-Making in Indeterminate Thyroid Nodules: A Global Meta-Analysis Across Test Generations.Endocrine pathology · 2026Pooled it
- The 2024 revised clinical guidelines on the management of thyroid tumors by the Japan Association of Endocrine Surgery.Endocrine journal · 2025Guideline
- Observational
- Medium-Term Study Results of Ultrasound-Guided Radiofrequency Ablation for Thyroid Follicular Neoplasm With Low SUV in PET/CT.International journal of endocrinology · 2026Article
- Patient-specific factors, patient preference, and nodule size as implications in the initial surgery of high risk indeterminate thyroid nodules.Endocrine · 2025Article
- Risk Stratification of Thyroid Nodules Diagnosed as Follicular Neoplasm on Core Needle Biopsy.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- Recent topics on thyroid cytopathology: reporting systems and ancillary studies.Journal of pathology and translational medicine · 2025Article
- Multimodal ultrasound radiomics model combined with clinical model for differentiating follicular thyroid adenoma from carcinoma.BMC medical imaging · 2025Article
- Cytopathology of follicular and oncocytic follicular thyroid neoplasms: A Bethesda System perspective.Cancer cytopathology · 2025Review
- Proposal for Clinical Management of Nodules Diagnosed as Atypia of Undetermined Significance via Thyroid Fine-Needle Aspiration Cytology in the Absence of Molecular Testing.Cytopathology : official journal of the British Society for Clinical Cytology · 2025Article
- Article
- Proposal for including risk of malignancy and clinical management in the Japanese system for reporting thyroid cytopathology - A multi-institutional study.CytoJournal · 2025Article
- Management of follicular thyroid carcinoma.European thyroid journal · 2024Review
- Evolutionary analysis of indeterminate cytology and risk of malignancy in a thyroid nodule unit.European thyroid journal · 2024Article
- Identification of invasive subpopulations using spatial transcriptome analysis in thyroid follicular tumors.Journal of pathology and translational medicine · 2024Article
- The Significance of RAS-Like Mutations and MicroRNA Profiling in Predicting Malignancy in Thyroid Biopsy Specimens.Endocrine pathology · 2022Article
- Criteria for follow-up of thyroid nodules diagnosed as follicular neoplasm without molecular testing - The experience of a high-volume thyroid centre in Japan.Diagnostic cytopathology · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical management of follicular neoplasms (FNs) using molecular testing of thyroid-aspirated materials is not routinely performed in Japan. This article aims to identify low-risk FN nodules that can be followed up without molecular testing.
methodsThe relationship between preoperative findings, factors influencing surgical decision, and the risk of malignancy (ROM) was examined in 356 thyroid nodules with cytological diagnosis of FN at Kuma Hospital from January to December 2020.
resultsROMs of FN with cytology results favouring malignancy (41.2%) were significantly higher than those favouring benign (7.7%) or borderline (8.2%) (p < .001). Moreover, ROMs of FN with ultrasonography results of high suspicion (54.5%) were significantly higher than those with low (4.5%) or intermediate suspicion (0%) (p < .0001). There was a large difference in overall ROM in tumours bordering 30 mm in size (<30 mm; 3.6%, ≥30 mm; 20.0%). ROMs of FNs with a tumour volume doubling rate (TVDR) of 1.0/year or more (28.6%) were higher than those of FNs with a lower TVDR (9.9%) (p < .05). The ROMs of FNs with or without one or more of the following four findings suggestive of malignancy: cytological findings favouring malignancy, ultrasonography findings of high suspicion, tumour size ≥30 mm, and TV-DR ≥1.0/year, were 14.6% and 1.0%, respectively.
conclusionFNs with no cytological findings favouring malignancy, no ultrasonography findings of high suspicion, tumour size <30 mm and TV-DR <1.0/year, are considered low risk and can be followed up without the need for molecular testing.
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