ArticleAngewandte Chemie (International ed. in English)2022
MOF-Hosted Enzymes for Continuous Flow Catalysis in Aqueous and Organic Solvents.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Biomineralization of Glucose Oxidase fromBioengineering (Basel, Switzerland) · 2026Article
- Porous Functional Nanomaterials for Continuous Flow Catalysis.Nano-micro letters · 2026Review
- Enhanced stability and reusability of recombinant silicatein upon biomimetic metal-organic framework crystallization.Chemical science · 2026Article
- Tailored Metal-Organic Framework-Based Enzyme Hybrids: Immobilization Strategies, Improved Performance, and Biological Applications.Small science · 2025Review
- Research and Developments of Heterogeneous Catalytic Technologies.Molecules (Basel, Switzerland) · 2025Review
- Diffusion-programmed catalysis in nanoporous material.Nature communications · 2025Article
- Organic and Metal-Organic Polymer-Based Catalysts-Enfant Terrible Companions or Good Assistants?Molecules (Basel, Switzerland) · 2024Review
- An enzymatic continuous-flow reactor based on a pore-size matching nano- and isoporous block copolymer membrane.Nature communications · 2024Article
- Organic-Solvent-Resistant Polyimide/Hydroxyapatite Mixed Matrix Membranes for Lysozyme Adsorption.Materials (Basel, Switzerland) · 2023Article
- Tandem-biocatalysis reactors constructed by topological evolution of CaCONature communications · 2023Article
- Recent Advances in Multifunctional Reticular Framework Nanoparticles: A Paradigm Shift in Materials Science Road to a Structured Future.Nano-micro letters · 2023Review
- Hierarchical covalent organic framework-foam for multi-enzyme tandem catalysis.Chemical science · 2023Article
- Exploring Oxidoreductases from Extremophiles for Biosynthesis in a Non-Aqueous System.International journal of molecular sciences · 2023Review
- Strategies for Transferring Photobiocatalysis to Continuous Flow Exemplified by Photodecarboxylation of Fatty Acids.ACS catalysis · 2022Article
- Boosting Protein Encapsulation through Lewis-Acid-Mediated Metal-Organic Framework Mineralization: Toward Effective Intracellular Delivery.Chemistry of materials : a publication of the American Chemical Society · 2022Article
- MOF-Hosted Enzymes for Continuous Flow Catalysis in Aqueous and Organic Solvents.Angewandte Chemie (International ed. in English) · 2022Article
- Systematic evaluation of agarose- and agar-based bioinks for extrusion-based bioprinting of enzymatically active hydrogels.Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fully exploiting the potential of enzymes in cell-free biocatalysis requires stabilization of the catalytically active proteins and their integration into efficient reactor systems. Although in recent years initial steps towards the immobilization of such biomolecules in metal-organic frameworks (MOFs) have been taken, these demonstrations have been limited to batch experiments and to aqueous conditions. Here we demonstrate a MOF-based continuous flow enzyme reactor system, with high productivity and stability, which is also suitable for organic solvents. Under aqueous conditions, the stability of the enzyme was increased 30-fold, and the space-time yield exceeded that obtained with other enzyme immobilization strategies by an order of magnitude. Importantly, the infiltration of the proteins into the MOF did not require additional functionalization, thus allowing for time- and cost-efficient fabrication of the biocatalysts using label-free enzymes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.