ReviewCurrent rheumatology reports2022
MRI in the Diagnosis and Treatment Response Assessment of Chronic Nonbacterial Osteomyelitis in Children and Adolescents.
Review in Current rheumatology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 36 citations in OpenAlex.
- The quiet flame: whole-body MRI and the underestimated burden of pediatric chronic non-bacterial osteomyelitis (CNO).European journal of pediatrics · 2026Article
- Chronic non-bacterial osteomyelitis presenting as fever of unknown origin in a child: a diagnostic pitfall.BMC pediatrics · 2026Article
- Physicians' perspectives on the diagnosis and treatment of adult SAPHO syndrome: a cross-sectional study from China.Clinical rheumatology · 2026Article
- Validation of the EULAR/ACR classification criteria for chronic nonbacterial osteomyelitis in a pediatric cohort.Clinical rheumatology · 2025Article
- Lesion distribution across the body in chronic non-bacterial osteomyelitis: an update.European journal of pediatrics · 2025Article
- Childhood Leukemia Presenting as Clinical Arthritis and Chronic Recurrent Multifocal Osteomyelitis: A Case Report.Oman medical journal · 2025Article
- Preferential involvement of the pelvis and hips along with active sacroiliitis in chronic nonbacterial osteomyelitis: MRI of 97 patients from a single tertiary referral center.European radiology · 2024Article
- Diagnostic and therapeutic practices in adult chronic nonbacterial osteomyelitis (CNO).Orphanet journal of rare diseases · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewTo explain the central role of magnetic resonance imaging (MRI) in the diagnosis and follow-up of chronic nonbacterial osteomyelitis (CNO) in children and adolescents, centering on practical technical aspects and salient diagnostic features. RECENT
findingsIn the absence of conclusive clinical features and widely accepted laboratory tests, including validated disease biomarkers, MRI (whether targeted or covering the entire body) currently plays an indispensable role in the diagnosis and therapy response assessment of CNO. Whole-body MRI, which is the reference imaging standard for CNO, can be limited to a short tau inversion recovery (STIR) coronal image set covering the entire body and a STIR sagittal set covering the spine, an approximately 30-min examination with no need for intravenous contrast or diffusion-weighted imaging. The hallmark of CNO is periphyseal (metaphyseal and/or epi-/apophyseal) osteitis, identified as bright foci on STIR, with or without inflammation of the adjacent periosteum and surrounding soft tissue. Response to bisphosphonate treatment for CNO has some unique MRI findings that should not be mistaken for residual or relapsing disease. Diagnostic features and treatment response characteristics of MRI in pediatric CNO are discussed, also describing the techniques used, pitfalls encountered, and differential diagnostic possibilities considered during daily practice.
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