Evidence map›Paper›PMID 35133556›Full record

Trial reportResearch on child and adolescent psychopathology2022

Children's Maternal Representations Moderate the Efficacy of Parent-Child Interaction Therapy-Emotion Development (PCIT-ED) Treatment For Preschool Depression.

Meghan Rose Donohue, Jenny Yin, Laura Quiñones-Camacho, Laura Hennefield, Rebecca Tillman, Kirsten Gilbert, Diana Whalen, Deanna M Barch, Joan Luby

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Research on child and adolescent psychopathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Preschool Mood Disorders: A Review of the Literature from 2017 to 2024.Child and adolescent psychiatric clinics of North America · 2025
    Review
  6. Review
  7. Novel mechanism-based treatments for pediatric anxiety and depressive disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meghan Rose DonohueDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA. rdonohue@wustl.edu.ORCID 0000-0001-8223-2275
Jenny YinDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Laura Quiñones-CamachoDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Laura HennefieldDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Rebecca TillmanDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Kirsten GilbertDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Diana WhalenDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Deanna M BarchDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Joan LubyDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.

Funding

Validation of Preschool Depressive SyndromeR01MH064769 · NIMH · WASHINGTON UNIVERSITY · PI LUBY, JOAN L. · 2003 to 2012
$7.7M
Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
Neurodevelopmental Emergence of Callous-Unemotional Behavior Beginning in Infancy: Neural Markers and Environmental Risk and Protective FactorsK23MH125023 · NIMH · WASHINGTON UNIVERSITY · PI DONOHUE, MEGHAN ROSE · 2021 to 2025
$904k
Influence of Physical Activity on Daily Positive Affect & Affective Neural Activity in PreschoolersK23MH118426 · NIMH · WASHINGTON UNIVERSITY · PI WHALEN, DIANA J · 2018 to 2022
$879k
Heightened Performance Monitoring and Overcontrol: Neural Markers and Caregiving Processes in Developmental Risk TrajectoriesK23MH115074 · NIMH · WASHINGTON UNIVERSITY · PI GILBERT, KIRSTEN · 2017 to 2021
$821k
The Development of Optimism in Preschool Age Children: Individual Differences and Implications for Resiliency and Mental HealthF32HD093273 · NICHD · WASHINGTON UNIVERSITY · PI HENNEFIELD, LAURA · 2017 to 2020
$173k
NICHD NIH HHS F32 HD093273NIH HHS F32HD093273NIH HHS K23MH115074NIMH NIH HHS K23 MH115074NIMH NIH HHS K23 MH118426NIMH NIH HHS K23MH118426NIMH NIH HHS K23 MH125023NIMH NIH HHS K23MH125023NIMH NIH HHS R01 MH064769NIMH NIH HHS R01MH064769-06A1NIMH NIH HHS T32 MH100019NIMH NIH HHS T32MH100019
6 · The paper itself

Abstract

A randomized controlled trial (RCT) demonstrated that a novel psychotherapy, Parent-Child Interaction Therapy-Emotion Development (PCIT-ED), effectively treats preschool-onset depression. However, little is known about which children benefit most from PCIT-ED. As positive parent-level factors are associated with lesser depressive symptoms, this study explored the potential moderating role of positive parenting relationships on PCIT-ED efficacy. This study examined mothers and their children aged 3-6 (N = 185) who participated in the PCIT-ED RCT. Children were randomized to immediate PCIT-ED treatment (n = 94) or a waitlist control condition (n = 91) that received treatment after 18 weeks. Prior to treatment, children completed a narrative story completion task that was videotaped and coded for children's positive and negative representations of their mothers. Parent-child interaction tasks were also completed pre-treatment and videotaped and coded to measure observed parenting. Odds of MDD diagnosis post-treatment were predicted by the interaction of children's negative maternal representations and treatment group (Estimate = -.68; SE = .27; [Formula: see text] = 6.45; p = .01) and the interaction of children's relatively more positive than negative maternal representations and treatment group (Estimate = .30; SE = .13; [Formula: see text] = 5.27; p = .02). Observed parenting measures did not significantly predict odds of MDD diagnosis. Thus, PCIT-ED predicted loss of MDD diagnosis for children who displayed maternal representations that were less negative, and relatively more positive than negative. Results suggest that children with relatively more positive maternal representations may be more likely to benefit from PCIT-ED, whereas children with more negative maternal representations may need targeted work to decrease negative maternal perceptions before initiating PCIT-ED in order for treatment to be most effective.

Indexed as

DepressionParent-Child RelationsChild, PreschoolEmotionsFemaleHumansParentingParentsMaternal representationsParent–child interventionPreschool depressionRandomized controlled trialTreatment moderators

Identifiers

PMID35133556
PMCPMC9808883

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.