Evidence map›Paper›PMID 35133531›Full record

ArticleWiener medizinische Wochenschrift (1946)2022

Chest CT severity score: assessment of COVID‑19 severity and short-term prognosis in hospitalized Iranian patients.

Alireza Aziz-Ahari, Mahsa Keyhanian, Setareh Mamishi, Shima Mahmoudi, Ebrahim Ebrahimi Bastani, Fatemeh Asadi, Mohammadreza Khaleghi

Abstract read
In one paragraph

Article in Wiener medizinische Wochenschrift (1946), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

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15citing papers in PubMed
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3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Alireza Aziz-AhariDepartment of Radiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mahsa KeyhanianDepartment of Radiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Setareh MamishiPediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Shima MahmoudiPediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Ebrahim Ebrahimi BastaniDepartment of Radiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Fatemeh AsadiSchool of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mohammadreza KhaleghiDepartment of Radiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. mkh712003@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to evaluate the value of chest computed tomography (CT) severity score in the assessment of coronavirus disease 2019 (COVID‑19) severity and short-term prognosis.

methodsIn this cross-sectional study, we evaluated all patients who were referred to our university hospital, from 21 May 2020 to 22 June 2020 with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription-polymerase chain reaction (RT-PCR) test. The patients suspected of having other respiratory diseases including influenza, according to an infectious disease specialist, and those without chest CT scan were excluded. A chest CT was obtained for all patients between days 4 and 7 days after symptom onset. Chest CT severity score was also calculated based on the degree of involvement of the lung lobes as 0%, (0 points), 1-25% (1 point), 26-50% (2 points), 51-75% (3 points), and 76-100% (4 points). The CT severity score was quantified by summing the 5 lobe indices (range 0-20). The ROC curve analysis was performed for the clinical value of CT scores in distinguishing the patients based on the severity of disease (mild/moderate group versus severe group), ICU admission, intubation requirement, and mortality.

resultsOf the 148 patients included, 93 patients recovered, while 55 patients died (mortality rate 37%). The area under the curve of CT score for discriminating of recovered patients from deceased individuals was 0.726, and the optimal CT score threshold was 15.5 with 61.8% sensitivity and 76.3% specificity. The best CT score cut-off for discriminating of patients based on the severity of disease was 12.5 with 68.3% sensitivity and 72.7% specificity. In addition, with CT score cut-off of 15.5, sensitivities of 70.8% and 51.6% and specificities of 78% and 72.6% were observed for intubation and ICU admission, respectively.

conclusionCT scan and semiquantitative scoring method could be beneficial and applicable in predicting the patient's condition.

Indexed as

COVID-19Cross-Sectional StudiesHumansIranLungPrognosisRetrospective StudiesSARS-CoV-2Tomography, X-Ray ComputedComputed tomography scanComputed tomography severity scoreCoronavirus disease 2019MortalitySeverity

Identifiers

PMID35133531
PMCPMC8824536

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.