ArticlePlanta2022
A truncated CC-NB-ARC gene TaRPP13L1-3D positively regulates powdery mildew resistance in wheat via the RanGAP-WPP complex-mediated nucleocytoplasmic shuttle.
Article in Planta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Fine mapping and candidate gene dissection of the wheat powdery mildew resistance gene PmPBDH.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
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- Employing AlphaFold and TED to explore the structural impacts of stress-associated mutations in rice.Bioinformatics advances · 2026Article
- Graph-based pangenomes and pan-phenome provide a cornerstone for eggplant biology and breeding.Nature communications · 2025Article
- Characterization and Fine Mapping of the Stay-Green-Related Spot Leaf GeneInternational journal of molecular sciences · 2025Article
- Genomic Signatures of Environmental Adaptation inPlants (Basel, Switzerland) · 2025Article
- A dual transcriptome analysis reveals accession-specific resistance responses inFrontiers in plant science · 2025Article
- Identification of nuclear membrane SUN proteins and components associated with wheat fungal stress responses.Stress biology · 2024Article
- Identification and functional characterization of theFrontiers in plant science · 2024Article
- Fighting wheat powdery mildew: from genes to fields.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Review
- A necessary considering factor for breeding: growth-defense tradeoff in plants.Stress biology · 2023Review
- Article
- TaSYP137 and TaVAMP723, the SNAREs Proteins from Wheat, Reduce Resistance toInternational journal of molecular sciences · 2023Article
- Combating powdery mildew: Advances in molecular interactions betweenFrontiers in plant science · 2022Review
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Authors and funding
10 authors.
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Abstract
MAIN
conclusionA wheat RPP13-like isoform interacting with WPP1 contributes to quantitative and/or basal resistance to powdery mildew (Blumeria graminis f. sp. tritici) by restricting the development of Bgt conidia. Plant disease resistance (R) genes confer an ability to resist infection by pathogens expressing specific avirulence genes. Recognition of Peronospora parasitica 13-like (RPP13-like) genes belong to the nucleotide-binding site and leucine-rich repeat (NBS-LRR) superfamily and play important roles in resistance to various plant diseases. Previously, we detected a TaRPP13-like gene located on chromosome 3D (TaRPP13L1-3D) in the TaSpl1 resided region, which is strongly induced by the cell death phenotype (Zhang et al. 2021). Here, we investigated the expression and functional role of TaRPP13L1-3D in wheat responding to fungal stress. TaRPP13L1-3D encoded a typical NB-ARC structure characterized by Rx-N and P-loop NTPase domains. TaRPP13L1-3D transcripts were strongly upregulated in wheat by powdery mildew (Blumeria graminis f. sp. tritici; Bgt) and stripe rust (Puccinia striiformis f. sp. tritici; Pst) infection although opposing expression patterns were observed in response to wheat-Bgt in incompatible and compatible backgrounds. Overexpression of TaRPP13L1-3D enhanced disease resistance to Bgt, accompanied by upregulation of the defense-related marker genes encoding phytoalexin-deficient4 (PAD4), thaumatin-like protein (TLP) and chitinase 8-like protein (Chi8L), while silencing of TaRPP13L1-3D disrupted the resistance to Bgt infection. Subcellular localization studies showed that TaRPP13L1-3D is located in both the plasma membrane and nucleus, while yeast-two-hybrid (Y2H) assays indicated that TaRPP13L1-3D interacts with WPP domain-containing protein 1 (TaWPP1). This indicates that TaRPP13L1-3D shuttles between the nucleus and cytoplasm membrane via a mechanism that is mediated by the RanGAP-WPP complex in nuclear pores. This insight into TaRPP13L1-3D will be useful in dissecting the mechanism of fungal resistance in wheat, and understanding the interaction between R gene expression and pathogen defense.
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