Evidence map›Paper›PMID 35133500›Full record

ReviewActa diabetologica2022

Diabetic macular ischemia.

Beatrice Tombolini, Enrico Borrelli, Riccardo Sacconi, Francesco Bandello, Giuseppe Querques

Abstract readReview
PubMed Publisher
In one paragraph

Review in Acta diabetologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Case series: The role of retinal ischemia in the pathogenesis and clinical manifestation of diabetic retinopathy.Optometry and vision science : official publication of the American Academy of Optometry · 2026
    Article
  2. Review
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  4. Posterior Retinal Ischemia Correlates With Vision in Patients With Diabetes.Investigative ophthalmology & visual science · 2025
    Observational
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  7. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Beatrice TomboliniSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Enrico BorrelliSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Riccardo SacconiSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Francesco BandelloSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Giuseppe QuerquesSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy. querques.giuseppe@unisr.it.ORCID http://orcid.org/0000-0002-3292-9581

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimSince its relevance on diagnosis and prognosis of diabetic retinopathy (DR), this review will examine a multimodal imaging approach to detect diabetic macular ischemia (DMI).

methodsA PubMed engine search was carried out using the term "macular ischemia" paired with "diabetes," and "diabetic macular ischemia" paired to "fluorescein angiography," "ultra-wide field fluorescein angiography," "optical coherence tomography angiography," "octa," "2D octa," "ultra-wide field octa," "3D octa," "visual acuity." All studies published in English up to October 2021 irrespective of their publication status were reviewed, and relevant publications were included in this review.

resultsRecently, new technologies have been proposed as an alternative to fluorescein angiography (FA), which is an actual diagnostic gold standard technique. Nowadays, optical coherence tomography angiography (OCTA) has emerged as the most promising and reliable procedure able to provide a qualitative and quantitative description of DMI. Newer three-dimensional (3D) OCTA approach will be discussed too. Moreover, we will discuss how OCTA might identify preclinical alterations before the onset of DR and allow prediction about the progression of disease.

conclusionOCTA has significantly expanded our knowledge on diabetic macular ischemia.

Indexed as

Diabetes MellitusDiabetic RetinopathyFluorescein AngiographyHumansIschemiaRetinal VesselsTomography, Optical CoherenceDiabetic macular ischemiaDiabetic retinopathyFluorescein angiographyFoveal avascular zoneOptical coherence tomography angiographyThree-dimensional

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.