Evidence map›Paper›PMID 35133471›Full record

ArticleCalcified tissue international2022

Bone Turnover Markers After Six Nights of Insufficient Sleep and Subsequent Recovery Sleep in Healthy Men.

Christine M Swanson, Prajakta Shanbhag, Emma J Tussey, Corey A Rynders, Kenneth P Wright, Wendy M Kohrt

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Calcified tissue international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03733483 (Mechanisms for Sleep/Circadian Disruption-Induced Impairments in Bone Formation), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03733483 nacompletednot on this map

Mechanisms for Sleep/Circadian Disruption-Induced Impairments in Bone Formation

TypeinterventionalSponsorUniversity of Colorado, DenverRan2019 to 2020Enrolled12ConditionsHealthyArmsSleep Deprivation
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christine M SwansonDivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave, Mail Stop 8106, Aurora, CO, 80045, USA. Christine.Swanson@CUAnschutz.edu.ORCID 0000-0003-1554-0862
Prajakta ShanbhagDivision of Geriatric Medicine, University of Colorado Anschutz Medical Campus, and Eastern Colorado VA Geriatric, Research, Education, and Clinical Center (GRECC), Aurora, CO, USA.
Emma J TusseyDivision of Geriatric Medicine, University of Colorado Anschutz Medical Campus, and Eastern Colorado VA Geriatric, Research, Education, and Clinical Center (GRECC), Aurora, CO, USA.
Corey A RyndersDivision of Geriatric Medicine, University of Colorado Anschutz Medical Campus, and Eastern Colorado VA Geriatric, Research, Education, and Clinical Center (GRECC), Aurora, CO, USA.
Kenneth P WrightDivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave, Mail Stop 8106, Aurora, CO, 80045, USA.
Wendy M KohrtDivision of Geriatric Medicine, University of Colorado Anschutz Medical Campus, and Eastern Colorado VA Geriatric, Research, Education, and Clinical Center (GRECC), Aurora, CO, USA.

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
The Collaboration Linking Opioid Use Disorder and Sleep ("CLOUDS") StudyU01HL150596 · NHLBI · YALE UNIVERSITY · PI BARRY, DECLAN T., REDEKER, NANCY S · 2019 to 2024
$5.1M
HIV-1, Insufficient Sleep and Vascular Endothelial DysfunctionR01HL131458 · NHLBI · UNIVERSITY OF COLORADO · PI CONNICK, ELIZABETH, DESOUZA, CHRISTOPHER A · 2016 to 2019
$3.0M
Sleep and Blood Pressure-Related Endothelial AbnormalitiesR01HL135598 · NHLBI · UNIVERSITY OF COLORADO · PI DESOUZA, CHRISTOPHER A, STAUFFER, BRIAN L · 2017 to 2020
$3.0M
Metabolic Effects of Sleep Extension in People with ObesityR01DK115502 · NIDDK · WASHINGTON UNIVERSITY · PI KLEIN, SAMUEL · 2018 to 2022
$2.9M
Sensitivity of the Circadian Clock to Light in Early ChildhoodR01HD087707 · NICHD · UNIVERSITY OF COLORADO · PI WRIGHT, KENNETH P · 2017 to 2021
$2.9M
Adaptive responses to overfeeding and weight regain in reduced obese individualsR01DK114272 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BESSESEN, DANIEL HOLLAND · 2018 to 2022
$2.5M
Fractured Schedules: Skeletal Effects of Acute and Chronic Night Shift WorkR01HL151332 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SWANSON, CHRISTINE M · 2021 to 2025
$1.8M
Sleep Disturbance: A Novel Risk Factor for Impaired Bone RemodelingK23AR070275 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI SWANSON, CHRISTINE M · 2016 to 2020
$853k
Time restricted feeding and metabolic rhythms in humansK01DK113063 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI RYNDERS, COREY ALLAN · 2017 to 2021
$832k
Bone Turnover Responses to Sleep Restriction and Subsequent Sleep RecoveryR03AR074509 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI SWANSON, CHRISTINE M · 2020 to 2021
$153k
NCATS NIH HHS UL1 TR002535NHLBI NIH HHS R01 HL131458NHLBI NIH HHS R01 HL135598NHLBI NIH HHS R01 HL151332NHLBI NIH HHS U01 HL150596NIAMS NIH HHS K23 AR070275NIAMS NIH HHS R03 AR074509NICHD NIH HHS R01 HD087707NIDDK NIH HHS K01 DK113063NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK114272NIDDK NIH HHS R01 DK115502
6 · The paper itself

Abstract

purposeThe goal of this study was to determine the bone turnover marker (BTM) response to insufficient and subsequent recovery sleep, independent of changes in posture, body weight, and physical activity.

methodsHealthy men (N = 12) who habitually slept 7-9 h/night were admitted to an inpatient sleep laboratory for a baseline 8 h/night sleep opportunity followed by six nights of insufficient sleep (5 h/night). Diet, physical activity, and posture were controlled. Serum markers of bone formation (osteocalcin, PINP) and resorption (β-CTX) were obtained over 24 h at baseline and on the last night of sleep restriction, and on fasted samples obtained daily while inpatient and five times after discharge over 3 weeks. Maximum likelihood estimates in a repeated measures model were used to assess the effect of insufficient and subsequent recovery sleep on BTM levels.

resultsThere was no statistically or clinically significant change in PINP (p = 0.53), osteocalcin (p = 0.66), or β-CTX (p = 0.10) in response to six nights of insufficient sleep. There were no significant changes in BTMs from the inpatient stay through 3 weeks of recovery sleep (all p [Formula: see text] 0.63). On average, body weight was stable during the inpatient stay (Δweight = - 0.55 ± 0.91 kg, p = 0.06).

conclusionNo significant changes in serum BTMs were observed after six nights of insufficient or subsequent recovery sleep in young healthy men. Changes in weight and physical activity may be required to observe significant BTM change in response to sleep and circadian disruptions. Clinical Trials Registration Registered at ClinicalTrials.gov (NCT03733483) on November 7, 2018.

Indexed as

SleepSleep DeprivationBiomarkersBody WeightBone RemodelingHumansMaleOsteocalcinBiomarkersOsteocalcinBone turnover markersInsufficient sleepRecovery sleepSleep restriction

Identifiers

PMID35133471
PMCPMC9117441

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.