ArticleAbdominal radiology (New York)2022
Correlation and prognostic value of CT-detected extramural venous invasion and pathological lymph-vascular invasion in colon cancer.
Article in Abdominal radiology (New York), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 11 citations in OpenAlex.
- Factors associated with lymph node metastasis and survival in T2 colon cancer.BMC gastroenterology · 2025Article
- Constructing a nomogram to predict overall survival of colon cancer based on computed tomography characteristics and clinicopathological factors.World journal of gastrointestinal oncology · 2024Article
- Study on the diagnostic value of MDCT extramural vascular invasion in preoperative N staging of gastric cancer patients.BMC medical imaging · 2024Article
- Prognostic impact of extramural venous invasion detected by contrast-enhanced CT colonography in colon cancer.BJS open · 2024Article
- Small arteriole sign: an imaging feature for staging T4a colon cancer.European radiology · 2024Article
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Authors and funding
7 authors at 1 institution in 2 countries.
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Abstract
purposeTo explore the association between CT-detected extramural vascular invasion (ctEMVI) and lymph-vascular invasion (LVI) in colon cancer, and analyze the prognostic value of ctEMVI in different conditions of LVI.
methodsThis single-center, retrospective study included 448 colon cancer patients from January 2015 to December 2017. Preoperative CT features and clinical and pathological data were collected. Associations between ctEMVI and LVI were tested. Univariate and multivariate logistic regression was performed. Multivariate Cox regression was performed adjusted with propensity score(PS). Kaplan-Meier method was used to compare survival differences between the ctEMVI and LVI groups. A 1:1 patient pairing was conducted using PS matching to assess the prognostic effect of ctEMVI in LVI subgroups.
resultsAmong the 448 patients, there were 261 men and 187 women, with an average age of 63 ± 12 years. The coincidence rate of ctEMVI and LVI was 73.9%. The k coefficient for identifying ctEMVI was 0.84. ctEMVI and LVI were both independent risk factors for overall survival (ctEMVI: HR 2.8, 95% CI 1.5-5.5; LVI: HR 2.2, 95% CI 1.2-4.1) and metastasis-free survival (ctEMVI: HR 3.3, 95% CI 1.7-6.4; LVI: HR 2.4, 95% CI 1.3-4.5) adjusted with PS. In the LVI(+) subgroup, the prognosis of ctEMVI(+) was significantly worse than that of ctEMVI(-); in the LVI(-) subgroup, the prognosis of different ctEMVI states was similar.
conclusionctEMVI is an independent prognostic risk factor and has different prognostic value in different LVI states. It is recommended to perform the evaluation in routine work, especially for patients with positive LVI.
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