ArticleeLife2022
Coupling of pupil- and neuronal population dynamics reveals diverse influences of arousal on cortical processing.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 104 citations in OpenAlex.
- Early intervention increases reactive joint attention in autistic preschoolers with arousal regulation as mediator.European child & adolescent psychiatry · 2025Trial
- Pre-stimulus pupil-linked arousal enhances initial stimulus availability and accelerates decay in iconic memory.Attention, perception & psychophysics · 2026Article
- Beyond neural oscillations: Stress-related aperiodic activity and aperiodic-oscillatory spectral covariation.iScience · 2026Article
- Pupil size is linked to opposite signal fluctuations between cortical BOLD and ventricular CSF.NeuroImage · 2026Article
- Dissociation in cross-feature integration between behavioral and pupil dilation responses in auditory deviant detection.iScience · 2026Article
- Windows to the goal: Pupillary working memory signatures prospectively adapt to task demands.iScience · 2026Article
- Pupil- and gaze dynamics track emotion content in naturalistic speech.Scientific reports · 2026Article
- Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Distinct sources of decision-related signals in visual cortex are represented in different local field potential bands.PLoS biology · 2026Article
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- Locus-Coeruleus Norepinephrine Functioning as a Predictor of Childhood Mental Health (LOCUS-MENTAL): Protocol for a Longitudinal Study.JMIR research protocols · 2026Article
- Respiration as a dynamic modulator of sensory sampling.Nature communications · 2026Article
- Pupil-linked arousal heterogeneously modulates cell-type-specific sensory processing.Science advances · 2026Article
- Locus coeruleus modulation of neurophysiological sensory selectivity differs in autism and other mental health conditions.Translational psychiatry · 2026Article
- Phasic and tonic arousal distinctly shape human decision bias.Communications biology · 2026Article
- Rhythmic sampling of multiple decision alternatives in the human brain.Nature communications · 2026Article
- The Contribution of the Locus Ceruleus-Norepinephrine System to the Coupling between Pupil-Linked Arousal and Cortical State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Rapid invisible frequency tagging (RIFT) does not evoke intermodulation components in the neural response.PloS one · 2026Article
- Pupil size predicts exploration through critical slowing in prefrontal dynamics.Communications biology · 2025Article
- Dimensionality reduction techniques in pupillometry research: A primer for behavioral scientists.Behavior research methods · 2025Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
Fluctuations in arousal, controlled by subcortical neuromodulatory systems, continuously shape cortical state, with profound consequences for information processing. Yet, how arousal signals influence cortical population activity in detail has so far only been characterized for a few selected brain regions. Traditional accounts conceptualize arousal as a homogeneous modulator of neural population activity across the cerebral cortex. Recent insights, however, point to a higher specificity of arousal effects on different components of neural activity and across cortical regions. Here, we provide a comprehensive account of the relationships between fluctuations in arousal and neuronal population activity across the human brain. Exploiting the established link between pupil size and central arousal systems, we performed concurrent magnetoencephalographic (MEG) and pupillographic recordings in a large number of participants, pooled across three laboratories. We found a cascade of effects relative to the peak timing of spontaneous pupil dilations: Decreases in low-frequency (2-8 Hz) activity in temporal and lateral frontal cortex, followed by increased high-frequency (>64 Hz) activity in mid-frontal regions, followed by monotonic and inverted U relationships with intermediate frequency-range activity (8-32 Hz) in occipito-parietal regions. Pupil-linked arousal also coincided with widespread changes in the structure of the aperiodic component of cortical population activity, indicative of changes in the excitation-inhibition balance in underlying microcircuits. Our results provide a novel basis for studying the arousal modulation of cognitive computations in cortical circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.