ArticlePhysiological reports2022
Acute mountain sickness and sleep disturbances differentially influence cognition and mood during rapid ascent to 3000 and 4050 m.
Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Effects of Transcutaneous Vagus Nerve Stimulation on Cerebral Perfusion and Cognitive Function Under Simulated High-Altitude Hypobaric Hypoxia.Brain and behavior · 2026Trial
- The contributions of nocturnal hypoxaemia and sleep disturbances to acute mountain sickness.Experimental physiology · 2026Article
- Exogenous ketone monoester supplementation: a potential alternative strategy to mitigate altitude sickness?European journal of applied physiology · 2026Review
- The independent predictive effect of insomnia symptoms before high-altitude exposure on acute mountain sickness: an observational study of healthy volunteers at 2726 m.Frontiers in psychiatry · 2026Article
- An empirical study on the relationship between state anxiety, acute mountain sickness, oxygen saturation, and rating of perceived exertion among graduate students during high-altitude mountaineering.Frontiers in psychology · 2026Article
- Sleep Bruxism and Hypobaric Hypoxia Exposure: Exploring the Physiological Association.Journal of clinical medicine · 2025Review
- Early adaptation to high-altitude: Mood and cognitive responses at simulated 4500 m.Physiological reports · 2025Article
- Closing the loop: autonomous intelligent control for hypoxia pre-acclimatization and high-altitude health management.National science review · 2025Review
- A review of methods for assessment of cognitive function in high-altitude hypoxic environments.Brain and behavior · 2024Review
- A diffusion tensor imaging-based multidimensional study of brain structural changes after long-term high-altitude exposure and their relationships with cognitive function.Frontiers in physiology · 2024Article
- Transcriptomic signatures of severe acute mountain sickness during rapid ascent to 4,300 m.Frontiers in physiology · 2024Article
- Observational
- Adaptation and altitude sickness: A 40-year bibliometric analysis and collaborative networks.Frontiers in public health · 2023Article
- Acute mountain sickness and sleep disturbances differentially influence cognition and mood during rapid ascent to 3000 and 4050 m.Physiological reports · 2022Article
- Sleep loss effects on physiological and cognitive responses to systemic environmental hypoxia.Frontiers in physiology · 2022Review
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6 authors.
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Abstract
The impact of acute mountain sickness (AMS) and sleep disturbances on mood and cognition at two altitudes relevant to the working and tourist population is unknown. Twenty unacclimatized lowlanders were exposed to either 3000 m (n = 10; 526 mmHg) or 4050 m (n = 10; 460 mmHg) for 20 h in a hypobaric chamber. AMS prevalence and severity was assessed using the Environmental Symptoms Questionnaire (ESQ) and an AMS-C score ≥ 0.7 indicated sickness. While sleeping for one night both at sea level (SL) and high altitude (HA), a wrist motion detector was used to measure awakenings (Awak, events/h) and sleep efficiency (Eff, %). If Eff was ≥85%, individuals were considered a good sleeper (Sleep+). Mood and cognition were assessed using the Automated Neuropsychological Assessment Metric and Mood Scale (ANAM-MS). The ESQ and ANAM-MS were administered in the morning both at SL and after 20 h at HA. AMS severity (mean ± SE; 1.82 ± 0.27 vs. 0.20 ± 0.27), AMS prevalence (90% vs. 10%), depression (0.63 ± 0.23 vs. 0.00 ± 0.24) Awak (15.6 ± 1.6 vs. 10.1 ± 1.6 events/h), and DeSHr (38.5 ± 6.3 vs. 13.3 ± 6.3 events/h) were greater (p < 0.05) and Eff was lower (69.9 ± 5.3% vs. 87.0 ± 5.3%) at 4050 m compared to 3000 m, respectively. AMS presence did not impact cognition but fatigue (2.17 ± 0.37 vs. 0.58 ± 0.39), anger (0.65 ± 0.25 vs. 0.02 ± 0.26), depression (0.63 ± 0.23 vs. 0.00 ± 0.24) and sleepiness (4.8 ± 0.4 vs. 2.7 ± 0.5) were greater (p < 0.05) in the AMS+ group. The Sleep- group, compared to the Sleep+ group, had lower (p < 0.05) working memory scores (50 ± 7 vs. 78 ± 9) assessed by the Sternberg 6-letter memory task, and lower reaction time fatigue scores (157 ± 17 vs. 221 ± 22), assessed by the repeated reaction time test. Overall, AMS, depression, DeSHr, and Awak were increased (p < 0.05) at 4050 m compared to 3000 m. In addition, AMS presence impacted mood while poor sleep impacted cognition which may deteriorate teamwork and/or increase errors in judgement at HA.
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