Evidence map›Paper›PMID 35133050›Full record

ArticleJournal of cardiovascular electrophysiology2022

Perpendicular catheter orientation during papillary muscle ablation results in larger, deeper lesions.

Udi Nussinovitch, Paul Wang, Sanjiv Narayan, Mohan Viswanathan, Nitish Badhwar, Lijun Zheng, William H Sauer, Duy T Nguyen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Udi NussinovitchSection of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
Paul WangSection of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
Sanjiv NarayanSection of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.ORCID 0000-0001-7552-5053
Mohan ViswanathanSection of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
Nitish BadhwarSection of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
Lijun ZhengSection of Cardiac Electrophysiology, Division of Cardiology, University of Colorado, Aurora, Colorado, USA.
William H SauerSection of Cardiac Electrophysiology, Division of Cardiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-7070-0307
Duy T NguyenSection of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.ORCID 0000-0001-6570-6010
Cardiovascular Institute of the South · USBrigham and Women's Hospital · USUniversity of Colorado Hospital · US

Funding

The Dynamics of Human Atrial FibrillationR01HL083359 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sanjiv M Narayan · 2008 to 2026
$7.9M
NHLBI NIH HHS R01 HL083359
6 · The paper itself

Abstract

introductionAblation of papillary muscles (PMs) for refractory ventricular arrhythmias can often be challenging. The catheter approach and orientation during ablation may affect optimal radiofrequency (RF) delivery. Yet, no previous study investigated the association between catheter orientation and PM lesion size. We evaluated ablation lesion characteristics with various catheter orientations relative to the PM tissue during open irrigated ablation, using a standardized, experimental setting.

methodsViable bovine PM was positioned on a load cell in a circulating saline bath. RF ablation was performed over PM tissue at 50 W, with the open irrigated catheter positioned either perpendicular or parallel to the PM surface. Applied force was 10 g. Ablation lesions were sectioned and underwent quantitative morphometric analysis.

resultsA catheter position oriented directly perpendicular to the PM tissue resulted in the largest ablation lesion volumes and depths compared with ablation with the catheter parallel to PM tissue (75.26 ± 8.40 mm

conclusionFor PM ablation, catheter orientation perpendicular to the PM tissue achieves more effective and larger ablation lesions, with greater lesion depth. This may have implications for the chosen ventricular access approach, the type of catheter used, consideration for remote navigation, and steerable sheaths.

Indexed as

Catheter AblationPapillary MusclesAnimalsCathetersCattleHeart VentriclesTherapeutic Irrigationcatheter orientationpapillary muscles (PM)radiofrequency ablation (RFA)ventricular arrhythmias (VAs)ventricular tachycardia (VT)

Identifiers

PMID35133050
PMCPMC9041130
OpenAlexW4210927327

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.