Evidence map›Paper›PMID 35132870›Full record

ArticleJournal of the American Heart Association2022

Myogenic Vasoconstriction Requires Canonical G

Yingqiu Cui, Mario Kassmann, Sophie Nickel, Chenglin Zhang, Natalia Alenina, Yoland Marie Anistan, Johanna Schleifenbaum, Michael Bader, Donald G Welsh, Yu Huang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Direct Vascular Effects of Angiotensin II (A Systematic Short Review).International journal of molecular sciences · 2024
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. The machinery of healthy vasoconstriction: an overview.Pflugers Archiv : European journal of physiology · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Insights Into the Role of Angiotensin-II ATHypertension (Dallas, Tex. : 1979) · 2024
    Review
  15. The ATMolecules (Basel, Switzerland) · 2023
    Review
  16. Vascular mechanotransduction.Physiological reviews · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Yingqiu CuiExperimental and Clinical Research Center (ECRC) a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine (MDC) Charité - Universitätsmedizin Berlin Berlin Germany.
Mario KassmannExperimental and Clinical Research Center (ECRC) a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine (MDC) Charité - Universitätsmedizin Berlin Berlin Germany.ORCID 0000-0002-4785-6530
Sophie NickelExperimental and Clinical Research Center (ECRC) a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine (MDC) Charité - Universitätsmedizin Berlin Berlin Germany.
Chenglin ZhangHeart and Vascular Institute and School of Biomedical Sciences Chinese University of Hong Kong China.
Natalia AleninaMax Delbrück Center for Molecular Medicine Berlin Germany.ORCID 0000-0002-6071-5433
Yoland Marie AnistanExperimental and Clinical Research Center (ECRC) a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine (MDC) Charité - Universitätsmedizin Berlin Berlin Germany.
Johanna SchleifenbaumExperimental and Clinical Research Center (ECRC) a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine (MDC) Charité - Universitätsmedizin Berlin Berlin Germany.
Michael BaderMax Delbrück Center for Molecular Medicine Berlin Germany.
Donald G WelshDepartment of Physiology and Pharmacology Robarts, Research Institute Western University London Ontario Canada.
Yu HuangHeart and Vascular Institute and School of Biomedical Sciences Chinese University of Hong Kong China.ORCID 0000-0002-1277-6784
Maik GollaschExperimental and Clinical Research Center (ECRC) a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine (MDC) Charité - Universitätsmedizin Berlin Berlin Germany.ORCID 0000-0003-2797-1934
Max Delbrück Center · DEChinese University of Hong Kong · HKCity University of Hong Kong · HKWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Blood pressure and tissue perfusion are controlled in part by the level of intrinsic (myogenic) arterial tone. However, many of the molecular determinants of this response are unknown. We previously found that mice with targeted disruption of the gene encoding the angiotensin II type 1a receptor (AT1AR) (

Indexed as

Adaptor Proteins, Signal TransducingReceptor, Angiotensin, Type 1VasoconstrictionAngiotensin IIAnimalsbeta-ArrestinsCerebral ArteriesMiceAdaptor Proteins, Signal TransducingAgtrap protein, mouseAngiotensin IIbeta-ArrestinsReceptor, Angiotensin, Type 1angiotensin II type 1a receptorarterial smooth musclebiased ligandsmyogenic vasoconstriction

Identifiers

PMID35132870
PMCPMC9245832
OpenAlexW4210840207

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.