Evidence map›Paper›PMID 35132863›Full record

ArticleJournal of the American Heart Association2022

Association of Diabetes Duration and Glycemic Control With Stroke Rate in Patients With Atrial Fibrillation and Diabetes: A Population-Based Cohort Study.

Husam Abdel-Qadir, Madison Gunn, Iliana C Lega, Andrea Pang, Peter C Austin, Sheldon M Singh, Cynthia A Jackevicius, Karen Tu, Paul Dorian, Douglas S Lee and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
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  6. Article
  7. The Role of Diabetes and SGLT2 Inhibitors in Cerebrovascular Diseases.Current neurology and neuroscience reports · 2025
    Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Husam Abdel-QadirWomen's College Hospital Toronto Canada.ORCID 0000-0002-7105-7931
Madison GunnSchulich School of Medicine Western University London ON Canada.
Iliana C LegaWomen's College Hospital Toronto Canada.
Andrea PangICES (Formerly Known as the Institute for Clinical Evaluative Sciences) Toronto Canada.
Peter C AustinICES (Formerly Known as the Institute for Clinical Evaluative Sciences) Toronto Canada.ORCID 0000-0003-3337-233X
Sheldon M SinghDepartment of Medicine University of Toronto Canada.ORCID 0000-0002-8210-3112
Cynthia A JackeviciusUniversity Health Network Toronto Canada.ORCID 0000-0001-5274-7251
Karen TuUniversity Health Network Toronto Canada.ORCID 0000-0003-0883-4934
Paul DorianDepartment of Medicine University of Toronto Canada.ORCID 0000-0002-8244-3520
Douglas S LeeUniversity Health Network Toronto Canada.ORCID 0000-0001-7078-745X
Dennis T KoICES (Formerly Known as the Institute for Clinical Evaluative Sciences) Toronto Canada.ORCID 0000-0001-6840-8051
University Health Network · CAUniversity of Toronto · CASunnybrook Health Science Centre · CAWestern University · CAInstitute for Clinical Evaluative Sciences · CA

Funding

CIHR FDN‐154333
6 · The paper itself

Abstract

Background There are limited data on the association of diabetes duration and glycemic control with stroke risk in atrial fibrillation (AF). Our objective was to study the association of diabetes duration and glycated hemoglobin (HbA1c) with the rate of stroke in people with diabetes and newly diagnosed AF. Methods and Results This was a population-based cohort study using linked administrative data sets. We studied 37 209 individuals aged ≥66 years diagnosed with AF in Ontario between April 2009 and March 2019, who had diabetes diagnosed 1 to 16 years beforehand. The primary outcome was hospitalization for stroke at 1 year. Cause-specific hazard regression was used to model the association of diabetes duration and glycated hemoglobin (HbA1c) with the rate of stroke. Restricted cubic spline analyses showed increasing hazard ratios (HR) for stroke with longer diabetes duration that plateaued after 10 years and increasing HRs for stroke with HbA1c levels >7%. Relative to patients with <5 years diabetes duration, stroke rates were significantly higher for patients with ≥10 years duration (HR, 1.45; 95% CI, 1.16-1.82;

Indexed as

Atrial FibrillationDiabetes MellitusStrokeAgedCohort StudiesGlycated HemoglobinGlycemic ControlHumansRisk AssessmentRisk FactorsGlycated Hemoglobinatrial fibrillationdiabetesdiabetes durationglycated hemoglobinstroke

Identifiers

PMID35132863
PMCPMC9245806
OpenAlexW4210832175

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.