Evidence map›Paper›PMID 35132806›Full record

ArticleESC heart failure2022

Heart transplantation outcomes in arrhythmogenic right ventricular cardiomyopathy: a contemporary national analysis.

Katherine Giuliano, Paul Scheel, Eric Etchill, Charles D Fraser, Alejandro Suarez-Pierre, Steven Hsu, Ilan S Wittstein, Edward K Kasper, Roberta Florido, Harikrishna Tandri and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Arrhythmogenic Right Ventricular Cardiomyopathy: A Comprehensive Review.Journal of cardiovascular development and disease · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Katherine GiulianoDivision of Cardiac Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2260-1854
Paul ScheelDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Eric EtchillDivision of Cardiac Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Charles D FraserDivision of Cardiac Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alejandro Suarez-PierreDepartment of Surgery, University of Colorado, Aurora, CO, USA.
Steven HsuDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ilan S WittsteinDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Edward K KasperDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Roberta FloridoDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Harikrishna TandriDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hugh CalkinsDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Chun W ChoiDivision of Cardiac Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kavita SharmaDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ahmet KilicDivision of Cardiac Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nisha A GilotraDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USUniversity of Colorado Anschutz Medical Campus · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsHeart failure is an increasingly recognized later stage manifestation of arrhythmogenic right ventricular cardiomyopathy (ARVC) that can require heart transplantation (HT) to appropriately treat. We aimed to study contemporary ARVC HT outcomes in a national registry. METHODS AND

resultsThe United Network for Organ Sharing registry was queried for HT recipients from 1/1994 through 2/2020. ARVC patients were compared with non-ARVC dilated, restrictive, and hypertrophic cardiomyopathy HT patients (HT for ischaemic and valvular disease was excluded from analysis). Post-HT survival was assessed using Kaplan-Meier estimates. A total of 189 of 252 (75%) waitlisted ARVC patients (median age 48 years, 65% male) underwent HT, representing 0.3% of the total 65 559 HT during the study time period. Annual frequency of HT for ARVC increased significantly over time. ARVC patients had less diabetes (5% vs. 17%, P < 0.001), less cigarette use (15% vs. 23%, P < 0.001), lower pulmonary artery and pulmonary capillary wedge pressures, and lower cardiac output than the 33 659 non-ARVC patients (P < 0.001). Ventricular assist device use was significantly lower in ARVC patients (8% vs. 32%, P < 0.001); 1 and 5 year post-HT survival was 97% and 93% for ARVC vs. 95% and 82% for non-ARVC HT recipients (P < 0.001). On adjusted multivariable Cox regression, ARVC had decreased risk of post-HT death compared with non-ARVC aetiologies (hazard ratio 0.48, 95% confidence interval 0.28-0.82, P = 0.008). Patients with ARVC also had lower risk of death or graft failure than non-ARVC patients (hazard ratio 0.51, 95% confidence interval 0.32-0.81, P = 0.004).

conclusionsIn the largest series of HT in ARVC, we found that HT is increasingly performed in ARVC, with higher survival compared with other cardiomyopathy aetiologies. The right ventricular predominant pathophysiology may require unique considerations for heart failure management, including HT.

Indexed as

Arrhythmogenic Right Ventricular DysplasiaHeart TransplantationFemaleHeart FailureHumansMaleMiddle AgedProportional Hazards ModelsRegistriesTreatment OutcomeArrhythmogenic right ventricular cardiomyopathyHeart failureHeart transplantationPost-transplant outcomes

Identifiers

PMID35132806
PMCPMC8934952
OpenAlexW4210924297

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.