Evidence map›Paper›PMID 35132796›Full record

ReviewSmall (Weinheim an der Bergstrasse, Germany)2022

Harnessing the Therapeutic Potential of Extracellular Vesicles for Biomedical Applications Using Multifunctional Magnetic Nanomaterials.

Letao Yang, Kapil D Patel, Christopher Rathnam, Ramar Thangam, Yannan Hou, Heemin Kang, Ki-Bum Lee

Abstract readReview
In one paragraph

Review in Small (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Microbial medicines: Unlocking the therapeutic potential of the microbiome in cancer treatment.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Review
  3. Review
  4. Article
  5. Advanced small extracellular vesicles delivery systems forExtracellular vesicles and circulating nucleic acids · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Exosome-mediated triple drug delivery enhances apoptosis in pancreatic cancer cells.Apoptosis : an international journal on programmed cell death · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Smart nanoplatforms for early detection and immune modulation in lung cancer.Frontiers in bioengineering and biotechnology · 2025
    Review
  17. Extracellular Vesicles for Disease Treatment.International journal of nanomedicine · 2025
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Letao YangDepartment of Chemistry and Chemical Biology, Rutgers-the State University of New Jersey, 123 Bevier Road, Piscataway, NJ, 08854, USA.ORCID 0000-0002-0572-9787
Kapil D PatelDepartment of Materials Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.ORCID 0000-0002-0393-9166
Christopher RathnamDepartment of Chemistry and Chemical Biology, Rutgers-the State University of New Jersey, 123 Bevier Road, Piscataway, NJ, 08854, USA.ORCID 0000-0003-3111-4687
Ramar ThangamDepartment of Materials Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.
Yannan HouDepartment of Chemistry and Chemical Biology, Rutgers-the State University of New Jersey, 123 Bevier Road, Piscataway, NJ, 08854, USA.ORCID 0000-0002-5499-6865
Heemin KangDepartment of Materials Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.ORCID 0000-0003-1359-2810
Ki-Bum LeeDepartment of Chemistry and Chemical Biology, Rutgers-the State University of New Jersey, 123 Bevier Road, Piscataway, NJ, 08854, USA.ORCID 0000-0002-8164-0047

Funding

Machine learning-enabled Comparative Transcriptomic Profiling to Validate NanoScript-induced Inner Ear Hair CellsR01DC016612 · NIDCD · RUTGERS, THE STATE UNIV OF N.J. · PI KWAN, KELVIN Y., LEE, KIBUM · 2018 to 2022
$2.8M
Nanoparticle-based synthetic transcription factor to induce stem cell myogenesisR21AR071101 · NIAMS · RUTGERS, THE STATE UNIV OF N.J. · PI LEE, KIBUM · 2017 to 2018
$371k
NIAMS NIH HHS R21 AR071101NIDCD NIH HHS R01 DC016612NIH HHS 1R01DC016612NIH HHS 3R01DC016612-01S1NIH HHS 3R01DC016612-04S1NIH HHS 3R01DC016612-04S2NIH HHS 5R01DC016612-02S1NIH HHS R21AR071101
6 · The paper itself

Abstract

Extracellular vesicles (e.g., exosomes) carrying various biomolecules (e.g., proteins, lipids, and nucleic acids) have rapidly emerged as promising platforms for many biomedical applications. Despite their enormous potential, their heterogeneity in surfaces and sizes, the high complexity of cargo biomolecules, and the inefficient uptake by recipient cells remain critical barriers for their theranostic applications. To address these critical issues, multifunctional nanomaterials, such as magnetic nanomaterials, with their tunable physical, chemical, and biological properties, may play crucial roles in next-generation extracellular vesicles (EV)-based disease diagnosis, drug delivery, tissue engineering, and regenerative medicine. As such, one aims to provide cutting-edge knowledge pertaining to magnetic nanomaterials-facilitated isolation, detection, and delivery of extracellular vesicles and their associated biomolecules. By engaging the fields of extracellular vesicles and magnetic nanomaterials, it is envisioned that their properties can be effectively combined for optimal outcomes in biomedical applications.

Indexed as

ExosomesExtracellular VesiclesNanostructuresMagnetic PhenomenaTheranostic Nanomedicinebiosensorsexosomesextracellular vesiclesmagnetic nanomaterialsnanobiotechnologynanomedicinetheranostics

Identifiers

PMID35132796
PMCPMC9344859

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.