ArticleRespirology (Carlton, Vic.)2022
Chest CT-assessed comorbidities and all-cause mortality risk in COPD patients in the BODE cohort.
Article in Respirology (Carlton, Vic.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Artificial Intelligence in Asthma and COPD: Current Status and Future Potential.Journal of clinical medicine · 2026Review
- Cardiovascular Events in COPD: Complementary Role of Cardiac Risk and Coronary Artery Calcium Scores.Chest · 2026Observational
- Assessment of Comorbidities in Chronic Obstructive Pulmonary Disease Patients by Chest High Resolution Computed Tomography (HRCT).Journal of clinical medicine · 2026Article
- A fully automated explainable predictive model for diagnosing pre-capillary and post-capillary pulmonary hypertension on routine unenhanced CT: results from the ASPIRE registry.European heart journal. Digital health · 2026Article
- Global trends and hotspots in AI applications for CT detection of chronic obstructive pulmonary disease: A bibliometric analysis from 2012 to 2024.Lasers in medical science · 2025Review
- Age- and sex-related changes in proximal humeral volumetric BMD assessed via chest CT with a deep learning-based segmentation model.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Early warning and stratification of the elderly cardiopulmonary dysfunction-related diseases: multicentre prospective study protocol.BMJ open · 2025Article
- Supporting clinical trial recruitment in COPD by leveraging lung cancer screening: an observational study.ERJ open research · 2025Article
- Towards early detection and disease interception of COPD across the lifespan.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Article
- Prevalence and Clinical Correlates of Radiologically Detected Coronary Artery Disease in Chronic Obstructive Pulmonary Disease: A Cross-Sectional Observational Study.American journal of respiratory and critical care medicine · 2025Observational
- Quality of Care and Outcomes of Inpatients with COPD: A Multi-Center Study in China.International journal of chronic obstructive pulmonary disease · 2025Observational
- Leveraging Computed Tomography Imaging to Detect Chronic Obstructive Pulmonary Disease and Concomitant Chronic Diseases.American journal of respiratory and critical care medicine · 2024Article
- ERS International Congress 2023: highlights from the Thoracic Oncology Assembly.ERJ open research · 2024Article
- A radiomics-based logistic regression model for the assessment of emphysema severity.Tuberkuloz ve toraks · 2023Article
- From Laënnec's Stethoscope to the Magic of Imaging, Big Data and Artificial Intelligence: A Timeline of Precision Medicine for Patients with Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2023Article
- GOLD 2023 Executive Summary: responses from the GOLD Scientific Committee.The European respiratory journal · 2023Article
- Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary.The European respiratory journal · 2023Article
- Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary.American journal of respiratory and critical care medicine · 2023Article
- Visual Ordinal Coronary Artery Calcium Score from Non-Gated Chest CT Predicts Mortality After Severe Chronic Obstructive Pulmonary Disease Exacerbation.International journal of chronic obstructive pulmonary disease · 2023Article
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Authors and funding
12 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveThe availability of chest computed tomography (CT) imaging can help diagnose comorbidities associated with chronic obstructive pulmonary disease (COPD). Their systematic identification and relationship with all-cause mortality have not been explored. Furthermore, whether their CT-detected prevalence differs from clinical diagnosis is unknown.
methodsThe prevalence of 10 CT-assessed comorbidities was retrospectively determined at baseline in 379 patients (71% men) with mild to severe COPD attending pulmonary clinics. Anthropometrics, smoking history, dyspnoea, lung function, exercise capacity, BODE (BMI, Obstruction, Dyspnoea and Exercise capacity) index and exacerbations rate were recorded. The prevalence of CT-determined comorbidities was compared with that recorded clinically. Over a median of 78 months of observation, the independent association with all-cause mortality was analysed. A 'CT-comorbidome' graphically expressed the strength of their association with mortality risk.
resultsCoronary artery calcification, emphysema and bronchiectasis were the most prevalent comorbidities (79.8%, 62.7% and 33.9%, respectively). All were underdiagnosed before CT. Coronary artery calcium (hazard ratio [HR] 2.09; 95% CI 1.03-4.26, p = 0.042), bronchiectasis (HR 2.12; 95% CI 1.05-4.26, p = 0.036) and low psoas muscle density (HR 2.61; 95% CI 1.23-5.57, p = 0.010) were independently associated with all-cause mortality and helped define the 'CT-comorbidome'.
conclusionThis study of COPD patients shows that systematic detection of 10 CT-diagnosed comorbidities, most of which were not detected clinically, provides information of potential use to patients and clinicians caring for them.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.