Evidence map›Paper›PMID 35132469›Full record

ArticleParasitology research2022

Profile of T and B lymphocytes in individuals resistant to Schistosoma mansoni infection.

Robson da Paixão de Souza, Maria Ilma Araújo, Diego Mota Lopes, Sérgio Costa Oliveira, Jamille Souza Fernandes, Kelvin Edson M de Jesus, Edgar M Carvalho, Ricardo Riccio Oliveira, Luciana Santos Cardoso

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Parasitology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Robson da Paixão de SouzaServiço de Imunologia, Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Rua João das Botas s/n, Canela, Salvador, BA, 40.110-160, Brazil.
Maria Ilma AraújoServiço de Imunologia, Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Rua João das Botas s/n, Canela, Salvador, BA, 40.110-160, Brazil.
Diego Mota LopesServiço de Imunologia, Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Rua João das Botas s/n, Canela, Salvador, BA, 40.110-160, Brazil.
Sérgio Costa OliveiraINCT-DT-CNPQ/MCT), Instituto Nacional de Ciência E Tecnologia Em Doenças Tropicais, Rua João das Botas s/n, Canela, Salvador, BA, 40.110-160, Brazil.
Jamille Souza FernandesCentro das Ciências Biológicas E da Saúde, Universidade Federal Do Oeste da Bahia, Barreiras, BA, Brazil.
Kelvin Edson M de JesusInstituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Rua Waldemar Falcão No. 121, Candeal, Salvador, BA, 40296-710, Brazil.
Edgar M CarvalhoServiço de Imunologia, Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Rua João das Botas s/n, Canela, Salvador, BA, 40.110-160, Brazil.
Ricardo Riccio OliveiraInstituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Rua Waldemar Falcão No. 121, Candeal, Salvador, BA, 40296-710, Brazil.
Luciana Santos CardosoServiço de Imunologia, Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Rua João das Botas s/n, Canela, Salvador, BA, 40.110-160, Brazil. lucianac@ufba.br.
Complexo Hospitalar Universitário Professor Edgard Santos · BRFundação Oswaldo Cruz · BRInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais · BRUniversidade Federal da Bahia · BRUniversidade Federal de Minas Gerais · BRUniversidade Federal do Oeste da Bahia · BR

Funding

CNPq/MST/INCT-DT 465229/2014-0FAPESB EDITAL 014/2013
6 · The paper itself

Abstract

The mechanisms involved in the development of resistance to infection/reinfection by Schistosoma mansoni still arouse great interest and controversy. Some authors demonstrate that resistance to infection is attributed to a mixed Th1 and Th2 response and resistance to reinfection after repeated treatments through mechanisms associated with the Th2 response. Through flow cytometry, the phenotypic characterization of B and T lymphocytes in individuals residing in endemic areas with low parasite loads over 10 years was evaluated for the first time in humans. In this study, individuals with low parasite loads for Schistosoma mansoni had a higher proportion of Th1 and Th2 cells. In addition, lymphocytes from these individuals showed a higher degree of expression of costimulatory molecules CD28 and CTLA-4 and regulatory molecules FoxP3 and IL-10, when compared to individuals with high parasite loads. Our data indicate that the control of the parasite load of S. mansoni must be associated with a Th1, Th2, and regulatory response, and that further studies are needed to elucidate the possibility of mechanisms associated with the hyporesponsiveness of lymphocytes from individuals with high parasite loads.

Indexed as

Schistosomiasis mansoniAnimalsB-LymphocytesHumansLymphocyte CountSchistosoma mansoniTh2 CellsB lymphocytesSchistosoma mansoniSchistosomiasisT lymphocytes

Identifiers

PMID35132469
OpenAlexW4210831128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.