Evidence map›Paper›PMID 35132468›Full record

ArticleJournal of neurology2022

J wave syndromes in patients with spinal and bulbar muscular atrophy.

Karoline Steinmetz, Boris Rudic, Martin Borggrefe, Kathrin Müller, Reiner Siebert, Wolfgang Rottbauer, Albert Ludolph, Dominik Buckert, Angela Rosenbohm

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07443449 (Connecting SBMA National Registries/Databases), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07443449 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Connecting SBMA National Registries/Databases: a Retrospective Study

TypeobservationalSponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo BestaRan2024 to 2026Enrolled700ConditionsSBMA, Spinal and Bulbar Muscular Atrophy (SBMA)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Guideline
  2. Best practice recommendations for the clinical care of spinal bulbar muscular atrophy.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Guideline
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Karoline SteinmetzDepartment of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Boris Rudic1st Department of Medicine, University Medical Centre Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Martin Borggrefe1st Department of Medicine, University Medical Centre Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Kathrin MüllerDepartment of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Reiner SiebertInstitute of Human Genetics, University of Ulm and Ulm University Medical Center, Ulm, Germany.
Wolfgang RottbauerDepartment of Cardiology, University of Ulm, Ulm, Germany.
Albert LudolphDepartment of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Dominik Buckert *Department of Cardiology, University of Ulm, Ulm, Germany.
Angela Rosenbohm *Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany. angela.rosenbohm@uni-ulm.de.ORCID http://orcid.org/0000-0001-9700-0338
Universität Ulm · DEGerman Centre for Cardiovascular Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMales with X-linked recessive spinobulbar muscular atrophy (SBMA) are reported to die suddenly and a Brugada electrocardiography (ECG) pattern may be present. A hallmark of this pattern is the presence of ST segment elevations in right precordial leads associated with an increased risk of sudden cardiac death.

objectiveWe aimed to detect subtle myocardial abnormalities using ECG and cardiovascular magnetic resonance imaging (CMR) in patients with SBMA.

methods30 SBMA patients (55.7 ± 11.9 years) and 11 healthy male controls underwent 12-lead ECGs were recorded using conventional and modified chest leads. CMR included feature-tracking strain analysis, late gadolinium enhancement and native T1 and T2 mapping.

resultsTestosterone levels were increased in 6/29 patients. Abnormal ECGs were recorded in 70%, consisting of a Brugada ECG pattern, early repolarization or fragmented QRS. Despite normal left ventricular ejection fraction (66 ± 5%), SBMA patients exhibited more often left ventricular hypertrophy as compared to controls (34.5% vs 20%). End-diastolic volumes were smaller in SBMA patients (left ventricular volume index 61.7 ± 14.7 ml/m

conclusionSBMA patients show abnormal ECGs and structural abnormalities, which may explain an increased risk of sudden death. These findings underline the importance of ECG screening, measurement of testosterone levels and potentially CMR imaging to assess cardiac risk factors.

Indexed as

Bulbo-Spinal Atrophy, X-LinkedMagnetic Resonance Imaging, CineArrhythmias, CardiacContrast MediaFibrosisGadoliniumHumansMaleMyocardiumPredictive Value of TestsStroke VolumeSyndromeTestosteroneVentricular Function, LeftContrast MediaGadoliniumTestosteroneBrugadaCardiac magnet resonance imagingEarly repolarizationJ wave syndromeSpinal and bulbar muscular atrophySudden cardiac death

Identifiers

PMID35132468
PMCPMC9217903
OpenAlexW4210758436

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.