Evidence map›Paper›PMID 35132455›Full record

ArticleCalcified tissue international2022

Bilateral Atypical Femur Fractures After Denosumab in a Bisphosphonate Naive Patient: A Case Report.

Jeremy Keng Meng Goh, Joyce Suang Bee Koh, Alvin Choong Meng Ng, Meng Ai Png, Tet Sen Howe

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Calcified tissue international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Latent metabolic bone disease, skeletal dysplasia and other conditions related to low bone formation among 38 patients with subtrochanteric femoral fractures: a retrospective observational study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Observational
  4. Article
  5. Atypical femoral fracture after denosumab for the treatment of osteoporosis in bisphosphonate naïve patients: two further cases.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jeremy Keng Meng GohDepartment of Orthopaedic Surgery, Singapore General Hospital, Outram Road Academia Building Level 4, Singapore, 119228, Singapore. jeremy.goh2@mohh.com.sg.ORCID 0000-0002-8864-7006
Joyce Suang Bee KohDepartment of Orthopaedic Surgery, Singapore General Hospital, Outram Road Academia Building Level 4, Singapore, 119228, Singapore.
Alvin Choong Meng NgMount Elizabeth Medical Centre, The Endocrine Clinic, 3 Mount Elizabeth #15-04, Singapore, 228510, Singapore.
Meng Ai PngDepartment of Diagnostic Radiology, Singapore General Hospital, Block 2, Level 1, Outram Road, Singapore, 169608, Singapore.
Tet Sen HoweDepartment of Orthopaedic Surgery, Singapore General Hospital, Outram Road Academia Building Level 4, Singapore, 119228, Singapore.
Singapore General Hospital · SGMount Elizabeth Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A case report of bilateral atypical femur fractures (AFF) in a bisphosphonate naive patient. A 62-year-old female bisphosphonate naive patient was started on denosumab for osteoporosis. Approximately 3 years later she complained of right hip pain and was found to have a bilateral incomplete AFFs. She was asymptomatic on the left lower limb. Patient was managed conservatively and placed on protected weight bearing on both legs. Symptoms subsequently resolved over a period of 3 months, although radiographic findings remained at approximately 1 year. AFFs may be associated with patients on denosumab therapy even without a prior history of bisphosphonate use. Patients should be counselled appropriately and monitored for such complications.

Indexed as

Bone Density Conservation AgentsDenosumabDiphosphonatesFemoral FracturesOsteoporosisFemaleHumansMiddle AgedPainBone Density Conservation AgentsDenosumabDiphosphonatesAtypical femur fracturesBisphosphonatesDenosumabOsteoporosisProliaStress fractures

Identifiers

PMID35132455
OpenAlexW4210831778

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.