Evidence map›Paper›PMID 35132367›Full record

ArticleCase reports in urology2022

Donor-Derived Urothelial Carcinoma in Renal Transplant Recipients.

Zhiyu Qian, Emily Chou, Jing Yang, Hanwei Zhang, HuiHui Ye, Sandy T Liu, Arnold I Chin

Open access · goldAbstract readCase Reports
In one paragraph

Article in Case reports in urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zhiyu QianDivision of Urology, Brigham and Women's Hospital, Harvard Medical School, USA.ORCID https://orcid.org/0000-0001-9953-3074
Emily ChouDepartment of Urology, David Geffen School of Medicine at UCLA, USA.
Jing YangDepartment of Pathology, David Geffen School of Medicine at UCLA, USA.
Hanwei ZhangDepartment of Urology, David Geffen School of Medicine at UCLA, USA.
HuiHui YeDepartment of Pathology, David Geffen School of Medicine at UCLA, USA.
Sandy T LiuDepartment of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine at UCLA, USA.
Arnold I ChinDepartment of Urology, David Geffen School of Medicine at UCLA, USA.ORCID https://orcid.org/0000-0002-6714-9200
University of California, Los Angeles · USBrigham and Women's Hospital · US

Funding

UCLA SPORE IN PROSTATE CANCERP50CA092131 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REITER, ROBERT E · 2002 to 2023
$42.6M
NCI NIH HHS P50 CA092131
6 · The paper itself

Abstract

Cancer is a significant cause of morbidity and mortality in recipients of renal transplantation. The vast majority develop from recipient origins, whereas donor-derived malignancies are exceedingly rare. We report 2 cases of poorly differentiated donor-derived urothelial carcinoma (UC) in renal transplantation recipients. The first patient underwent a living-related-donor renal transplantation 24 years prior and presented with back pain, hematuria, and rising creatinine and was found to have a 14 cm mass in the renal allograft with regional lymphadenopathy and liver metastases. Pathology showed UC with small-cell differentiation. The second patient presented with hematuria and rising creatinine and was initially found to have muscle invasive bladder cancer seven years after a deceased donor renal transplantation. Nine months after radical cystectomy, a large 9 cm mass was found on his allograft, for which radical nephrectomy and excision of prior ileal conduit was performed. Pathology showed UC with sarcomatoid differentiation. Short tandem repeat (STR) genotyping confirmed donor-derived origins. Both patient tumors expressed PD-L1 suggesting an additional therapeutic avenue for these rare tumors.

Identifiers

PMID35132367
PMCPMC8817887
OpenAlexW4210516690

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.