ArticleNature neuroscience2022
Mice alternate between discrete strategies during perceptual decision-making.
Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers.
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145 citing papers in PubMed.
- Neural and autonomic predictors of future listening errors.bioRxiv : the preprint server for biology · 2026Article
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- Uncovering internal states with a robust shared-state multi-neuron GLM-HMM framework.bioRxiv : the preprint server for biology · 2026Article
- Ecological Visual Processing in the Mouse.Annual review of neuroscience · 2026Review
- Neural and computational correlates of strategic aborting and long-run policy optimization in the dorsolateral prefrontal cortex.Nature communications · 2026Article
- Diurnal rhythms of choice: a novel state-dependent drift diffusion model uncovers time-dependent changes in rat decision making.Research square · 2026Article
- Addressing degeneracy in rodent studies of cognition.Current opinion in neurobiology · 2026Review
- Diurnal rhythms of choice: a novel state-dependent drift diffusion model uncovers time-dependent changes in rat decision making.bioRxiv : the preprint server for biology · 2026Article
- Quantifying uncertainty in drift diffusion models of decision making under temporal dependence and parameter variability.bioRxiv : the preprint server for biology · 2026Article
- The anterior cingulate cortex modulates pupil-linked arousal.Science advances · 2026Article
- Sex-specific behavioral feedback modulates sensorimotor processing and drives flexible social behavior.Nature communications · 2026Article
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- Cerebellar acceleration of learning in an evidence-accumulation task.Cell reports · 2026Article
- Sharing the spotlight: Uncovering common attentional dynamics across species.PLoS computational biology · 2026Article
- Revealing abrupt transitions from goal-directed to habitual behavior.Nature communications · 2026Article
- Building Goal-Directed Cognitive Graphs.bioRxiv : the preprint server for biology · 2026Article
85 more citing papers are in PubMed but not listed here.
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8 authors.
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Abstract
Classical models of perceptual decision-making assume that subjects use a single, consistent strategy to form decisions, or that decision-making strategies evolve slowly over time. Here we present new analyses suggesting that this common view is incorrect. We analyzed data from mouse and human decision-making experiments and found that choice behavior relies on an interplay among multiple interleaved strategies. These strategies, characterized by states in a hidden Markov model, persist for tens to hundreds of trials before switching, and often switch multiple times within a session. The identified decision-making strategies were highly consistent across mice and comprised a single 'engaged' state, in which decisions relied heavily on the sensory stimulus, and several biased states in which errors frequently occurred. These results provide a powerful alternate explanation for 'lapses' often observed in rodent behavioral experiments, and suggest that standard measures of performance mask the presence of major changes in strategy across trials.
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