Evidence map›Paper›PMID 35132152›Full record

Observational studyJournal of perinatology : official journal of the California Perinatal Association2022

Associations between maternal pre-pregnancy body mass index and neonatal neurobehavior in infants born before 30 weeks gestation.

Nina P Nosavan, Lynne M Smith, Lynne M Dansereau, Mary B Roberts, Julie A Hofheimer, Brian S Carter, Jennifer B Helderman, Elisabeth C McGowan, Charles R Neal, Steve Pastyrnak and 3 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Nina P NosavanDepartment of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
Lynne M SmithDepartment of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA. smith@lundquist.org.ORCID 0000-0002-3086-9167
Lynne M DansereauBrown Center for the Study of Children at Risk, Women and Infants Hospital, Providence, RI, USA.
Mary B RobertsCenter for Primary Care and Prevention, Care New England Medical Group, Pawtucket, RI, USA.
Julie A HofheimerDepartment of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.ORCID 0000-0003-3233-1480
Brian S CarterDepartment of Pediatrics, Children's Mercy Hospital, Kansas City, MO, USA.ORCID 0000-0003-0539-9164
Jennifer B HeldermanDepartment of Pediatrics, Wake Forest School of Medicine, Winston Salem, NC, USA.
Elisabeth C McGowanDepartment of Pediatrics, Brown Alpert Medical School and Women and Infants Hospital, Providence, RI, USA.
Charles R NealDepartment of Pediatrics, University of Hawaii John A Burns School of Medicine, Honolulu, HI, USA.
Steve PastyrnakDepartment of Pediatrics, Spectrum Health - Helen DeVos Hospital, Grand Rapids, MI, USA.
Sheri A Della GrottaBrown Center for the Study of Children at Risk, Women and Infants Hospital, Providence, RI, USA.
T Michael O'SheaDepartment of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Barry M LesterBrown Center for the Study of Children at Risk, Women and Infants Hospital, Providence, RI, USA.
Providence College · USUCLA Medical Center · USUniversity of North Carolina at Chapel Hill · USWomen & Infants Hospital of Rhode Island · USChildren's Mercy Hospital · USSpectrum Health · USUniversity of Hawaiʻi at Mānoa · USWake Forest University · US

Funding

ENVIRONMENTAL INFLUENCES ON NEURODEVELOPMENTAL OUTCOME IN INFANTS BORN VERY PRETERMUH3OD023347 · OD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LESTER, BARRY M., MARSIT, CARMEN JOSEPH · 2018 to 2022
$18.4M
Neonatal Neurobehavior and Outcomes in Very Preterm InfantsR01HD072267 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LESTER, BARRY M., O'SHEA, MICHAEL · 2013 to 2017
$3.3M
NICHD NIH HHS R01 HD072267
6 · The paper itself

Abstract

objectiveTo examine the relationship between maternal pre-pregnancy body mass index (BMI) and neonatal neurobehavior in very premature infants. STUDY

designMulti-center prospective observational study of 664 very preterm infants with 227 born to obese mothers. The NICU Network Neurobehavioral Scale (NNNS) assessed neurobehavior at NICU discharge.

resultsElevated BMI combined with infection increased the odds of having the most poorly regulated NNNS profile by 1.9 times per BMI SD. Infants born to mothers with elevated BMI in combination with: infection had poorer self-regulation, chorioamnionitis had increased asymmetrical reflexes, diabetes had poorer attention, and low SES required more handling.

conclusionMaternal pre-pregnancy BMI alone did not affect short-term neonatal neurobehavior in infants born before 30 weeks gestation. Infants born to mothers with elevated pre-pregnancy weight in addition to infections, diabetes, or socioeconomic adversity demonstrated increased risk of having the most poorly regulated NNNS profile and deficits in multiple domains.

Indexed as

Infant, PrematureInfant, Premature, DiseasesBody Mass IndexFemaleGestational AgeHumansInfantInfant, NewbornMothersPregnancy

Identifiers

PMID35132152
PMCPMC9007858
OpenAlexW4210920579

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.