ArticleNature communications2022
Spatial-temporal dynamics of a microbial cooperative behavior resistant to cheating.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Biosurfactants direct the evolutionary dynamics of surface-associated microbial systems.Science advances · 2026Article
- Measuring Communication in Microbial Biofilms in Response to Antibiotics, Phytochemicals and Stressors.Antioxidants (Basel, Switzerland) · 2026Article
- Integrative systems biology approaches for analyzing microbiome dysbiosis and species interactions.Briefings in bioinformatics · 2025Review
- Spatial population dynamics of bacterial colonies with social antibiotic resistance.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Ecological design of high-performance synthetic microbial communities: from theoretical foundations to functional optimization.ISME communications · 2025Review
- The collapse of cooperation during range expansion of Pseudomonas aeruginosa.Nature microbiology · 2024Article
- Unraveling plant-microbe interactions: can integrated omics approaches offer concrete answers?Journal of experimental botany · 2024Article
- Reciprocal signaling between quorum sensing mutants: A model for division of labor.microPublication biology · 2024Article
- Cooperation in bioluminescence: understanding the role of autoinducers by a stochastic random resistor model.The European physical journal. E, Soft matter · 2023Article
- Cooperative antibiotic resistance facilitates horizontal gene transfer.The ISME journal · 2023Article
- Agent-based methods facilitate integrative science in cancer.Trends in cell biology · 2023Review
- High-Throughput Gel Microbeads as Incubators for Bacterial Competition Study.Micromachines · 2023Article
- Eco-evolutionary modelling of microbial syntrophy indicates the robustness of cross-feeding over cross-facilitation.Scientific reports · 2023Article
- Dynamic proteome allocation regulates the profile of interaction of auxotrophic bacterial consortia.Royal Society open science · 2022Article
Corrections and comments
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Authors and funding
8 authors.
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Abstract
Much of our understanding of bacterial behavior stems from studies in liquid culture. In nature, however, bacteria frequently live in densely packed spatially-structured communities. How does spatial structure affect bacterial cooperative behaviors? In this work, we examine rhamnolipid production-a cooperative and virulent behavior of Pseudomonas aeruginosa. Here we show that, in striking contrast to well-mixed liquid culture, rhamnolipid gene expression in spatially-structured colonies is strongly associated with colony specific growth rate, and is impacted by perturbation with diffusible quorum signals. To interpret these findings, we construct a data-driven statistical inference model which captures a length-scale of bacterial interaction that develops over time. Finally, we find that perturbation of P. aeruginosa swarms with quorum signals preserves the cooperating genotype in competition, rather than creating opportunities for cheaters. Overall, our data demonstrate that the complex response to spatial localization is key to preserving bacterial cooperative behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.