ArticleNature communications2022
Primate anterior insular cortex represents economic decision variables proposed by prospect theory.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Complementary and opponent value signals in the human brain support choosing the best and avoiding the worst.Nature communications · 2026Article
- Neural representations of dynamical state and trait impulsivity in individuals at risk for internet gaming disorder.Molecular psychiatry · 2026Article
- Closed-loop readout of anterior insula high-gamma activity steers value-based decisions.Nature communications · 2026Article
- Differences in other-directed emotion regulation tracks connectivity between amygdala and prefrontal regions during fairness decisions.bioRxiv : the preprint server for biology · 2026Article
- Social hierarchy influences monkeys' risky decisions.Communications biology · 2026Article
- Value coding by primate amygdala neurons complies with the continuity axiom of economic choice theory.Journal of neurophysiology · 2026Article
- Modeling information demand in the framework of probabilistic reasoning.Communications psychology · 2026Article
- Neural representation of the decisional reference point in monkeys.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Comparison of independence axiom violations across primates: humans and monkeys.Journal of economic behavior & organization · 2025Article
- Dynamic coding and sequential integration of multiple reward attributes by primate amygdala neurons.Nature communications · 2025Article
- The Isle of Craig: Neuroanatomical and Functional Evidence for a Role of the Insular Cortex in Subjective Feelings.Current topics in behavioral neurosciences · 2025Review
- Ventral frontostriatal circuitry mediates the computation of reinforcement from symbolic gains and losses.Neuron · 2024Article
- Direct stimulation of anterior insula and ventromedial prefrontal cortex disrupts economic choices.Nature communications · 2024Article
- Neuronal Activity in the Gustatory Cortex during Economic Choice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Computational Mechanisms Underlying Motivation to Earn Symbolic Reinforcers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The amygdala and the pursuit of future rewards.Frontiers in neuroscience · 2024Review
- Asymmetric coding of reward prediction errors in human insula and dorsomedial prefrontal cortex.Nature communications · 2023Article
- Article
- Electrophysiological population dynamics reveal context dependencies during decision making in human frontal cortex.Nature communications · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In humans, risk attitude is highly context-dependent, varying with wealth levels or for different potential outcomes, such as gains or losses. These behavioral effects have been modelled using prospect theory, with the key assumption that humans represent the value of each available option asymmetrically as a gain or loss relative to a reference point. It remains unknown how these computations are implemented at the neuronal level. Here we show that macaques, like humans, change their risk attitude across wealth levels and gain/loss contexts using a token gambling task. Neurons in the anterior insular cortex (AIC) encode the 'reference point' (i.e., the current wealth level of the monkey) and reflect 'loss aversion' (i.e., option value signals are more sensitive to change in the loss than in the gain context) as postulated by prospect theory. In addition, changes in the activity of a subgroup of AIC neurons correlate with the inter-trial fluctuations in choice and risk attitude. Taken together, we show that the primate AIC in risky decision-making may be involved in monitoring contextual information used to guide the animal's willingness to accept risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.