ArticleNeurology2022
Impact of Small Vessel Disease Progression on Long-term Cognitive and Functional Changes After Stroke.
Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Ischemic stroke-specific cognitive dysfunction: a bibliometric analysis of research evolution.Frontiers in neurology · 2026Pooled it
- Targeting the muscle-brain axis to improve post-stroke cognition via the FNDC5/irisin/BDNF pathway.Journal of advanced research · 2026Article
- A composite measure of cerebral small vessel disease predicts cognitive change after stroke.medRxiv : the preprint server for health sciences · 2026Article
- Plasma GFAP and NLRP3 Associate with Cognitive Impairment After Recent Small Subcortical Infarct via Periventricular White Matter Hyperintensity.CNS neuroscience & therapeutics · 2026Article
- Ability to Detect Digital Risks: Effects of an Educational Intervention and Dementia Risk Level.International journal of environmental research and public health · 2025Article
- Prevalence of white matter hyperintensities and radiological cerebral small vessel disease: an insight from routinely collected data.BMC neurology · 2025Article
- Functional, Cognitive, Physical, and Vascular Outcomes 9 Years After Lacunar and Mild Cortical Ischemic Stroke.Neurology · 2025Observational
- Predictive Markers of Post-Stroke Cognitive Recovery and Depression in Ischemic Stroke Patients: A 6-Month Longitudinal Study.European journal of investigation in health, psychology and education · 2024Article
- Association of Cerebrovascular Reactivity With 1-Year Imaging and Clinical Outcomes in Small Vessel Disease: An Observational Cohort Study.Neurology · 2024Observational
- Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress.Journal of the American Heart Association · 2024Article
- The volume and the distribution of premorbid white matter hyperintensities: Impact on post-stroke aphasia.Human brain mapping · 2024Article
- Blood-Brain Barrier Breakdown is a Sensitive Biomarker of Cognitive and Language Impairment in Patients with White Matter Hyperintensities.Neurology and therapy · 2023Article
- Review
- Targeted photothrombotic subcortical small vessel occlusion using in vivo real-time fiber bundle endomicroscopy in mice.Biomedical optics express · 2023Article
- Magnetic resonance imaging and neuropsychological findings for predicting of cognitive deterioration in memory clinic patients.Frontiers in aging neuroscience · 2023Article
- Associations of Peak-Width Skeletonized Mean Diffusivity and Post-Stroke Cognition.Life (Basel, Switzerland) · 2022Article
- Diabetes mellitus exacerbates changes in white matter hyperintensity shapes and volume: A longitudinal study.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesThe severity of white matter hyperintensities (WMH) at presentation with stroke is associated with poststroke dementia and dependency. However, WMH can decrease or increase after stroke; prediction of cognitive decline is imprecise; and there are few data assessing longitudinal interrelationships among changing WMH, cognition, and function after stroke, despite the clinical importance.
methodsWe recruited patients within 3 months of a minor ischemic stroke, defined as NIH Stroke Scale (NIHSS) score <8 and not expected to result in a modified Rankin Scale (mRS) score >2. Participants repeated MRI at 1 year and cognitive and mRS assessments at 1 and 3 years. We ran longitudinal mixed-effects models assessing change in Addenbrooke's Cognitive Examination-Revised (ACE-R) and mRS scores. For mRS score, we assessed longitudinal WMH volumes (cube root; percentage intracranial volume [ICV]), adjusting for age, NIHSS score, ACE-R, stroke subtype, and time to assessment. For ACE-R score, we additionally adjusted for ICV, mRS, premorbid IQ, and vascular risk factors. We then used a multivariate model to jointly assess changing cognition/mRS score, adjusted for prognostic variables, using all available data.
resultsWe recruited 264 patients; mean age was 66.9 (SD 11.8) years; 41.7% were female; and median mRS score was 1 (interquartile range 1-2). One year after stroke, normalized WMH volumes were associated more strongly with 1-year ACE-R score (β = -0.259, 95% CI -0.407 to -0.111 more WMH per 1-point ACE-R decrease, DISCUSSION: After stroke, fluctuating WMH mean that 1-year, but not baseline, WMH volumes are associated strongly with contemporaneous cognitive scores. Covarying longitudinal decline in cognition and independence after stroke, central to dementia diagnosis, is associated with increasing WMH volumes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.