ArticleProceedings of the National Academy of Sciences of the United States of America2022
Dark-field computed tomography reaches the human scale.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Feasibility of longitudinal in vivo monitoring of pulmonary disease progression in mouse models using laboratory-based x-ray dark-field CT.European radiology experimental · 2026Article
- Adaptive filtering method for reducing signal saturation induced artifacts in X-ray dark-field tomography.Scientific reports · 2026Article
- On the optimization of the geometric pattern for structured illumination based X-ray phase contrast and dark-field imaging: a simulation study and its experimental validation.Journal of synchrotron radiation · 2026Article
- Demonstration of a family of X-ray dark-field retrieval approaches on a common set of samples.Journal of synchrotron radiation · 2026Article
- Advanced X-Ray Imaging Technology.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Synchrotron radiation based analyzer-free dual-phase dark-field lung imaging approach for radiography and CT.Scientific reports · 2025Article
- High-energy X-ray phase-contrast CT of an adult human chest phantom.Scientific reports · 2025Article
- Imaging technologies in experimental pulmonary fibrosis research: essential tool for enhanced translational relevance.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Evaluating the feasibility of region-of-interest X-ray phase contrast imaging for lung cancer diagnostics.Scientific reports · 2025Article
- Quantifying grating defects in X-ray Talbot-Lau interferometry through a comparative study of two fabrication techniques.Scientific reports · 2025Article
- T staging esophageal tumors with x rays.Optica · 2024Article
- X-ray dark-field computed tomography for monitoring of tissue freezing.Scientific reports · 2024Article
- Grating-based x-ray dark-field CT for lung cancer diagnosis in mice.European radiology experimental · 2024Article
- First experimental evaluation of a high-resolution deep silicon photon-counting sensor.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Alpha-fetoprotein, glypican-3, and kininogen-1 as biomarkers for the diagnosis of hepatocellular carcinoma.International journal of clinical and experimental pathology · 2024Review
- Recent developments in X-ray diffraction/scattering computed tomography for materials science.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2023Review
- [Dark-field imaging and computed tomography : Novel X-ray-based contrast imaging modality with great promise for pulmonary imaging].Radiologie (Heidelberg, Germany) · 2023Review
- Towards virtual histology with X-ray grating interferometry.Scientific reports · 2023Article
- The choice of an autocorrelation length in dark-field lung imaging.Scientific reports · 2023Article
- Self-aligned multi-layer X-ray absorption grating using large-area fabrication methods for X-ray phase-contrast imaging.Scientific reports · 2023Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
X-ray computed tomography (CT) is one of the most commonly used three-dimensional medical imaging modalities today. It has been refined over several decades, with the most recent innovations including dual-energy and spectral photon-counting technologies. Nevertheless, it has been discovered that wave-optical contrast mechanisms-beyond the presently used X-ray attenuation-offer the potential of complementary information, particularly on otherwise unresolved tissue microstructure. One such approach is dark-field imaging, which has recently been introduced and already demonstrated significantly improved radiological benefit in small-animal models, especially for lung diseases. Until now, however, dark-field CT could not yet be translated to the human scale and has been restricted to benchtop and small-animal systems, with scan durations of several minutes or more. This is mainly because the adaption and upscaling to the mechanical complexity, speed, and size of a human CT scanner so far remained an unsolved challenge. Here, we now report the successful integration of a Talbot-Lau interferometer into a clinical CT gantry and present dark-field CT results of a human-sized anthropomorphic body phantom, reconstructed from a single rotation scan performed in 1 s. Moreover, we present our key hardware and software solutions to the previously unsolved roadblocks, which so far have kept dark-field CT from being translated from the optical bench into a rapidly rotating CT gantry, with all its associated challenges like vibrations, continuous rotation, and large field of view. This development enables clinical dark-field CT studies with human patients in the near future.
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