ArticleProceedings of the National Academy of Sciences of the United States of America2022
A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Population-Level Implications of Parental Similarity for the Prevalence and Heritability of Psychiatric Disorders.JAMA psychiatry · 2026Article
- Mapping the heritability of disease: a nationwide study.Nature communications · 2026Article
- Multimodal analysis disentangles the genetic and microbial associations between inflammatory bowel disease and other immune-mediated diseases across a harmonized population framework.Nature communications · 2026Article
- The relationship between genotype- and phenotype-based estimates of genetic liability to psychiatric disorders, in practice and in theory.American journal of human genetics · 2026Article
- Spousal correlations for nine psychiatric disorders are consistent across cultures and persistent over generations.Nature human behaviour · 2025Article
- Familial co-aggregation and shared heritability between clinically diagnosed neurodevelopmental problems and cardiometabolic conditions: a nationwide register study across three generations.Research square · 2025Article
- Shared genetic architecture between eating disorders, mental health conditions, and cardiometabolic diseases: a comprehensive population-wide study across two countries.Nature communications · 2025Article
- Large-scale evidence of a general disease ('Psychological medicine · 2025Article
- Breast and bowel cancers diagnosed in people 'too young to have cancer': A blueprint for research using family and twin studies.Genetic epidemiology · 2024Article
- Genetic liability estimated from large-scale family data improves genetic prediction, risk score profiling, and gene mapping for major depression.American journal of human genetics · 2024Article
- Uncovering the heritable components of multimorbidities and disease trajectories using a nationwide cohort.Nature communications · 2024Article
- Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians.Nature communications · 2024Article
- Quantifying the Relative Importance of Genetics and Environment on the Comorbidity between Mental- and Cardiometabolic Disorders: A Comprehensive Analysis of National Register Data from 17 million Scandinavians.medRxiv : the preprint server for health sciences · 2024Article
- Fitness consequences of depressive symptoms vary between generations: Evidence from a large cohort of women across the 20th century.PloS one · 2024Article
- Perspective: the evolution of hormones and person perception-a quantitative genetic framework.Frontiers in psychology · 2024Article
- Applying an evolutionary mismatch framework to understand disease susceptibility.PLoS biology · 2023Article
- Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry).International journal of epidemiology · 2023Article
- Epidemiological overview of major depressive disorder in Scandinavia using nationwide registers.The Lancet regional health. Europe · 2023Article
- Diverse environmental perturbations reveal the evolution and context-dependency of genetic effects on gene expression levels.Genome research · 2022Article
- Family studies in the age of big data.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
For more than half a century, Denmark has maintained population-wide demographic, health care, and socioeconomic registers that provide detailed information on the interaction between all residents and the extensive national social services system. We leverage this resource to reconstruct the genealogy of the entire nation based on all individuals legally residing in Denmark since 1968. We cross-reference 6,691,426 individuals with nationwide health care registers to estimate heritability and genetic correlations of 10 broad diagnostic categories involving all major organs and systems. Heritability estimates for mental disorders were consistently the highest across demographic cohorts (average
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